Bulpitt C J, Shaw K, Clifton P, Stern G, Davies J B, Reid J L
Clin Neuropharmacol. 1985;8(2):175-83. doi: 10.1097/00002826-198506000-00007.
One hundred and eighty-one patients with treated Parkinson's disease completed a self-administered questionnaire on symptoms, and their responses were compared with those of 263 control subjects randomly selected from a general practice population. Nine symptoms were reported by the patients with more than a fivefold excess when compared with the controls. These included jerking of the limbs, shaking of the hands, excessive salivation, poor mental concentration, grimacing, being frozen or rooted to the spot, and hallucinations. Compared with the general control population, the patients did not have an excess of stomach or limb pain, indigestion, headache, or any decrease of interest in sex. This observational survey, unlike a randomised controlled trial, could not ensure that the different treatment groups were comparable in important respects. However, certain associations were apparent; for example, patients receiving both a decarboxylase inhibitor and levodopa tended to report fewer attacks of being frozen to the spot, fewer problems with salivation, and a reduced frequency of defaecation. Patients receiving anticholinergic drugs reported an excess of dry mouth, faintness, and dyskinesia, and fewer hot flushes.
181名接受过治疗的帕金森病患者完成了一份关于症状的自填式问卷，并将他们的回答与从普通诊所人群中随机选取的263名对照受试者的回答进行了比较。与对照组相比，患者报告的9种症状出现频率高出五倍以上。这些症状包括肢体抽搐、手部颤抖、流涎过多、注意力不集中、做鬼脸、身体僵住或呆立不动以及幻觉。与普通对照人群相比，患者没有出现胃部或肢体疼痛、消化不良、头痛增多的情况，也没有出现任何性欲减退的情况。与随机对照试验不同，这项观察性调查无法确保不同治疗组在重要方面具有可比性。然而，某些关联是明显的；例如，同时接受脱羧酶抑制剂和左旋多巴治疗的患者往往报告身体僵住发作的次数减少、流涎问题减少以及排便频率降低。接受抗胆碱能药物治疗的患者报告口干、头晕和运动障碍增多，潮热减少。
