Jain Amit Kumar, Parikh Purvish M, Dadhich Subash Chandra, Arora Anil, Kumar Mandhir, Ranjan Piyush, Bansal Naresh Kumar, Sharma Praveen, Aggarwal Shyam, Selvasekar C, Rawat Saumitra
Department of Medical Oncology, Jain Hospital, Bengaluru, Karnataka, India.
Department of Clinical Hematology, Sri Ram Cancer Center, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, India.
South Asian J Cancer. 2025 Jan 28;13(4):305-308. doi: 10.1055/s-0045-1802333. eCollection 2024 Oct.
Familial adenomatous polyposis is an important hereditary risk factor for colon cancer. Such patients and families need special attention for prevention, early detection, and optimal treatment. Molecular testing is key to identify the specific mutation in the proband and can then make it easier to identify other family members at risk. Aggressive surveillance and colonoscopy will be indicated in most patients. Both colonic and extra-colonic manifestations are important. Chemoprevention is worth considering. Almost all patients will ultimately need colectomy. These details will be discussed in this review.
家族性腺瘤性息肉病是结肠癌的一个重要遗传风险因素。此类患者及其家族在预防、早期检测和最佳治疗方面需要特别关注。分子检测是识别先证者特定突变的关键，进而便于识别其他有风险的家庭成员。大多数患者需要积极监测和结肠镜检查。结肠和结肠外表现都很重要。化学预防值得考虑。几乎所有患者最终都需要进行结肠切除术。这些细节将在本综述中讨论。
