Natarajan Prabhu Manickam, Swamikannu Bhuminathan, Bhavani Leela, Kamaraj Bindu, Kamaraj Loganathan, Veerakumar Ramachandran
Department of Clinical Sciences, College of Dentistry, Centre of Medical and Bio-allied Health Sciences and Research, Ajman University, Ajman, UAE.
Department of Prosthodontics, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 5):S4242-S4244. doi: 10.4103/jpbs.jpbs_1305_24. Epub 2025 Jan 30.
Oral cancer remains a significant public health concern globally, with smoking identified as a primary risk factor. This abstract reviews the role of smoking in the etiology of oral cancer, emphasizing its contribution to carcinogenesis through the induction of genetic mutations, oxidative stress, and inflammation. Tobacco smoke contains carcinogenic compounds such as polycyclic aromatic hydrocarbons, nitrosamines, and heavy metals, which are implicated in the transformation of oral mucosal cells. Epidemiological studies consistently demonstrate a dose-response relationship between smoking intensity and oral cancer risk. Despite advances in prevention and treatment, smoking cessation remains a critical component in reducing oral cancer incidence. This review underscores the importance of public health initiatives and targeted interventions aimed at mitigating smoking-related oral cancer risk.
口腔癌在全球范围内仍然是一个重大的公共卫生问题，吸烟被确定为主要风险因素。本摘要回顾了吸烟在口腔癌病因学中的作用，强调其通过诱导基因突变、氧化应激和炎症对致癌作用的贡献。烟草烟雾中含有多环芳烃、亚硝胺和重金属等致癌化合物，这些化合物与口腔黏膜细胞的转化有关。流行病学研究一致表明吸烟强度与口腔癌风险之间存在剂量反应关系。尽管在预防和治疗方面取得了进展，但戒烟仍然是降低口腔癌发病率的关键因素。本综述强调了公共卫生举措和旨在降低与吸烟相关的口腔癌风险的针对性干预措施的重要性。
