Liu Baohua, Yang Yisi, Zhou Hongguo, Liu Huan, Xu Zhenzhen
Department of Elderly Care and Management, School of Health Services and Wellness, Ningbo College of Health Sciences, Ningbo, Zhejiang, People's Republic of China.
Institute for STD and HIV/AIDS Prevention and Control, Harbin Center for Disease Control and Prevention, Harbin, Heilongjiang, People's Republic of China.
Patient Prefer Adherence. 2025 Mar 4;19:583-591. doi: 10.2147/PPA.S495212. eCollection 2025.
Treatment regimen fatigue (TRF) is universal among people living with HIV/AIDS. Long-term adherence to treatment regimens is crucial to maintaining the health and life span of such individuals.
This study aimed to examine treatment regimen fatigue among people living with HIV/AIDS and the relevant factors.
This cross-sectional study was conducted between January and December 2019 at two designated AIDS medical institutions in Harbin, China. A total of 717 valid samples were included in the study. The Treatment Regimen Fatigue Scale was used to measure treatment regimen fatigue. The participants responded to several questions regarding their demographic characteristics, clinical characteristics, and social psychological characteristics. Multivariate logistic regression assessed the relationship between TRF and associated factors. Odds ratios (OR) and 95% confidence intervals (CI) for OR were calculated.
The self-reported mean global score for the TRFS was -15.59 ± 22.90. After adjusted location, education background and, monthly income, the logistic regression model indicated that depression (OR=3.177, 95% CI=2.180-4.629), other chronic diseases (OR=1.786, 95% CI=1.057-3.019), >3 years of treatment (OR=1.767, 95% CI=1.203-2.594), having an intimate confidant (OR=0.514, 95% CI=0.347-0.760), life satisfaction (OR=0.564, 95% CI=0.365-0.870), living area (OR=0.491, 95% CI=0.295-0.817), and an undergraduate or above education level (OR = 0.568, 95% CI=0.335-0.965) were associated factors for TRF.
The prevalence of TRF among PLWHA in China is relatively high and is influenced by multiple factors including psychosocial, clinical, and demographic characteristics. Social support, especially psychological support, for PLWHA should be strengthened. This study's findings highlight the need to develop multilevel interventions to reduce TRF, addressing the complex needs of PLWHA and mitigating the adverse impact of TRF on HIV treatment outcomes. Further longitudinal research on factors of TRF should be conducted to strengthen and broaden the current findings.
治疗方案疲劳（TRF）在艾滋病毒/艾滋病感染者中普遍存在。长期坚持治疗方案对于维持这些人的健康和寿命至关重要。
本研究旨在调查艾滋病毒/艾滋病感染者的治疗方案疲劳情况及相关因素。
本横断面研究于2019年1月至12月在中国哈尔滨的两家指定艾滋病医疗机构进行。共纳入717份有效样本。使用治疗方案疲劳量表来测量治疗方案疲劳。参与者回答了几个关于他们的人口统计学特征、临床特征和社会心理特征的问题。多因素逻辑回归分析评估了TRF与相关因素之间的关系。计算优势比（OR）及其95%置信区间（CI）。
TRFS的自我报告平均总体评分为-15.59±22.90。在调整了居住地、教育背景和月收入后，逻辑回归模型表明，抑郁（OR=3.177，95%CI=2.180-4.629）、其他慢性病（OR=1.786，95%CI=1.057-3.019）、治疗时间>3年（OR=1.
