嗜盐酶的药物应用。
Pharmaceutical applications of halophilic enzymes.
作者信息
Yavari-Bafghi Maryam, Amoozegar Mohammad Ali
机构信息
Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
出版信息
Heliyon. 2025 Feb 17;11(4):e42754. doi: 10.1016/j.heliyon.2025.e42754. eCollection 2025 Feb 28.
Halophiles produce extraordinarily stable enzymes under conditions where conventional enzymes cease to function, denature, and precipitate. Halophilic enzymes have adapted to function optimally at high salt concentrations besides tolerance of organic solvents and thermal stability. These special features offer potential advantages of cost-effectiveness and improved treatment outcomes that make them valuable for pharmaceutical purposes including the synthesis, design, and discovery of new drugs. The article highlights the unique characteristics and adaptation strategies of halophiles towards salinity. It provides an overview of halophilic enzymes' pharmaceutical applications and examines different challenges, opportunities, and recent advances in applying these enzymes in this field.
嗜盐菌在传统酶停止发挥作用、变性和沉淀的条件下能产生极其稳定的酶。嗜盐酶除了耐受有机溶剂和具有热稳定性外，还适应在高盐浓度下发挥最佳功能。这些特殊特性具有成本效益高和治疗效果更好的潜在优势，使其在包括新药合成、设计和发现在内的制药用途中具有价值。本文着重介绍了嗜盐菌对盐度的独特特性和适应策略。它概述了嗜盐酶的制药应用，并探讨了在该领域应用这些酶时面临的不同挑战、机遇以及最新进展。
Zotero 插件