Pohlschroder Mechthild, Schulze Stefan, Pfeiffer Friedhelm, Hong Yirui
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Thomas H. Gosnell School of Life Sciences, College of Science, Rochester Institute of Technology, Rochester, New York, USA.
J Bacteriol. 2025 Jun 24;207(6):e0006225. doi: 10.1128/jb.00062-25. Epub 2025 May 14.
Archaea, once thought limited to extreme environments, are now recognized as ubiquitous and fundamental players in global ecosystems. While morphologically similar to bacteria, they are a distinct domain of life and are evolutionarily closer to eukaryotes. The development of model archaeal systems has facilitated studies that have underscored unique physiological, biochemical, and genetic characteristics of archaea. stands out as a model archaeon due to its ease of culturing, ability to grow on defined media, amenability to genetic and biochemical methods, as well as the support from a highly collaborative community. This haloarchaeon has been instrumental in exploring diverse aspects of archaeal biology, ranging from polyploidy, replication origins, and post-translational modifications to cell surface biogenesis, metabolism, and adaptation to high-salt environments. The extensive use of further catalyzed the development of new technologies and databases, facilitating discovery-driven research that offers significant implications for biotechnology, biomedicine, and core biological questions.
古菌，曾经被认为只存在于极端环境中，现在被公认为是全球生态系统中无处不在的重要参与者。虽然在形态上与细菌相似，但它们是一个独特的生命领域，在进化上更接近真核生物。模型古菌系统的发展促进了相关研究，这些研究突出了古菌独特的生理、生化和遗传特征。由于其易于培养、能够在限定培养基上生长、适合遗传和生化方法，以及有一个高度协作的社区的支持，[具体古菌名称未给出]作为一种模式古菌脱颖而出。这种嗜盐古菌在探索古菌生物学的各个方面发挥了重要作用，从多倍体、复制起点和翻译后修饰到细胞表面生物发生、代谢以及对高盐环境的适应。[具体古菌名称未给出]的广泛应用进一步推动了新技术和数据库的发展，促进了发现驱动的研究，这对生物技术、生物医学和核心生物学问题具有重要意义。
