肠道微生物群作为抗癌治疗的新靶点：从作用机制到调控手段
Gut microbiota as a new target for anticancer therapy: from mechanism to means of regulation.
作者信息
Sun Jiaao, Song Shiyan, Liu Jiahua, Chen Feng, Li Xiaorui, Wu Guangzhen
机构信息
Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Department of oncology, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
出版信息
NPJ Biofilms Microbiomes. 2025 Mar 11;11(1):43. doi: 10.1038/s41522-025-00678-x.
In order to decipher the relationship between gut microbiota imbalance and cancer, this paper reviewed the role of intestinal microbiota in anticancer therapy and related mechanisms, discussed the current research status of gut microbiota as a biomarker of cancer, and finally summarized the reasonable means of regulating gut microbiota to assist cancer therapy. Overall, our study reveals that the gut microbiota can serve as a potential target for improving cancer management.
为了解析肠道微生物群失衡与癌症之间的关系，本文综述了肠道微生物群在抗癌治疗中的作用及相关机制，探讨了肠道微生物群作为癌症生物标志物的研究现状，最后总结了调节肠道微生物群以辅助癌症治疗的合理方法。总体而言，我们的研究表明，肠道微生物群可作为改善癌症治疗的潜在靶点。
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