Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Int J Mol Sci. 2020 Feb 5;21(3):1055. doi: 10.3390/ijms21031055.
Curcumin, an herbal naturally occurring polyphenol, has recently been proposed for the treatment of neurodegenerative, neurological and cancer diseases due to its pleiotropic effect. Recent studies indicated that dysbiosis is associated with the abovementioned and other diseases, and gut microflora may be a new potential therapeutic target. The new working hypothesis that could explain the curative role of curcumin, despite its limited availability, is that curcumin acts indirectly on the brain, affecting the "gut-brain-microflora axis", a complex two-way system in which the gut microbiome and its composition, are factors that preserve and determine brain health. It is therefore suspected that curcumin and its metabolites have a direct regulatory effect on gut microflora and vice versa, which may explain the paradox between curcumin's poor bioavailability and its commonly reported therapeutic effects. Curcumin and its metabolites can have health benefits by eliminating intestinal microflora dysbiosis. In addition, curcumin undergoes enzymatic modifications by bacteria, forming pharmacologically more active metabolites than their parent, curcumin. In this review, we summarize a number of studies that highlight the interaction between curcumin and gut microbiota and vice versa, and we consider the possibility of microbiome-targeted therapies using curcumin, particularly in disease entities currently without causal treatment.
姜黄素是一种天然存在的多酚草药，由于其多效作用，最近被提议用于治疗神经退行性、神经和癌症疾病。最近的研究表明，肠道菌群失调与上述疾病和其他疾病有关，肠道微生物群可能是一个新的潜在治疗靶点。新的工作假设可以解释姜黄素的治疗作用，尽管其可用性有限，即姜黄素间接作用于大脑，影响“肠道-大脑-微生物群轴”，这是一个复杂的双向系统，其中肠道微生物群及其组成是维持和决定大脑健康的因素。因此，人们怀疑姜黄素及其代谢物对肠道微生物群有直接的调节作用，反之亦然，这可能解释了姜黄素生物利用度差与其通常报道的治疗效果之间的矛盾。姜黄素及其代谢物可以通过消除肠道微生物群失调来带来健康益处。此外，姜黄素通过细菌发生酶修饰，形成比母体姜黄素具有更高药理活性的代谢物。在这篇综述中，我们总结了一些强调姜黄素与肠道微生物群相互作用的研究，并且我们考虑了使用姜黄素进行微生物组靶向治疗的可能性，特别是在目前没有因果治疗的疾病实体中。
