Whateley T L, Steele G
Eur J Nucl Med. 1985;10(7-8):353-7. doi: 10.1007/BF00251311.
The change in particle size of the liver scanning tin colloid radiopharmaceutical (Amerscan) has been determined using the non-perturbing method of photon correlation spectroscopy. Although samples of the tin colloid taken from the preparation vial immediately after preparation and allowed to remain undisturbed in the light scattering cell grow to sizes of ca. 1,200 nm radius, when samples are taken by syringe from the preparation vial at varying times, the particle size is only ca. 400 nm radius. This effect has been shown to be due to shear deflocculation within the syringe needle. Thus, as the tin colloid is always administered in the clinical situation with a syringe, the size of particle which the patient receives is satisfactory for liver uptake. The tin colloid has been shown to be essentially a charge-stabilised colloidal system from measurements of both zeta potential and effect of electrolyte on the flocculation process.
已使用光子相关光谱法的非干扰方法测定了肝脏扫描用锡胶体放射性药物（Amerscan）的粒径变化。尽管制备后立即从制备瓶中取出并在光散射池中保持不受干扰的锡胶体样品会生长到半径约为1200nm的尺寸，但当在不同时间用注射器从制备瓶中取样时，粒径仅约为400nm半径。已证明这种效应是由于注射器针头内的剪切解絮凝作用。因此，由于在临床情况下锡胶体总是用注射器给药，患者接受的颗粒大小对于肝脏摄取是令人满意的。从zeta电位测量以及电解质对絮凝过程的影响来看，锡胶体已被证明基本上是一个电荷稳定的胶体系统。
