Hilditch T E, Elliott A T, Murray T, Whateley T L
Nucl Med Commun. 1986 Nov;7(11):845-50. doi: 10.1097/00006231-198611000-00008.
The effect of prolonged continuous movement on particle size within a 99Tcm-tin colloid preparation was investigated, making use of photon correlation spectroscopy for size estimation. No increase in particle size was found when the preparation was left undisturbed for up to 7 h, the mean (+/- S.D.) size being found to be 239 +/- 24 nm. When the preparation was placed in a laboratory rotator for the same period of time, there was a gradual increase in mean particle size to 404 +/- 127 nm. The increase in size was much greater, however, after 7 h of continuous agitation in a laboratory shaker, a mean value of 2260 +/- 746 nm being observed. An antimony sulphide colloid was subjected to continuous agitation for the same period of time but there was no evidence of aggregation. It is supposed that continuous movement of reconstituted 99Tcm-tin colloid, leading to a marked increase in particle size, may explain occasional instances of significant lung intake.
利用光子相关光谱法进行粒径估算，研究了长时间持续移动对99锝 - 锡胶体制剂中粒径的影响。当制剂静置长达7小时时，未发现粒径增加，平均（±标准差）粒径为239±24纳米。当制剂在实验室旋转器中放置相同时间时，平均粒径逐渐增加至404±127纳米。然而，在实验室振荡器中连续搅拌7小时后，粒径增加幅度更大，观察到平均值为2260±746纳米。硫化锑胶体在相同时间段内进行连续搅拌，但没有聚集的迹象。据推测，重构的99锝 - 锡胶体的持续移动导致粒径显著增加，这可能解释了偶尔出现的肺部大量摄取的情况。
