患有持续性室内环境相关症状或慢性疲劳的患者的生活质量与心理灵活性、抑郁、焦虑或失眠症状之间的关联。
The association between quality of life and psychological flexibility, depressive, anxiety or insomnia symptoms in patients with persistent indoor environment-related symptoms or chronic fatigue.
作者信息
Selinheimo Sanna, Vuokko Aki, Lappalainen Päivi, Keinonen Katariina, Sainio Markku, Lappalainen Raimo, Paunio Tiina
机构信息
Finnish Institute of Occupational Health, Helsinki, Finland.
Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.
出版信息
BMC Psychol. 2025 Mar 11;13(1):229. doi: 10.1186/s40359-025-02549-8.
BACKGROUND
Persistent physical symptoms (PPS) can significantly impair health-related quality of life (HRQoL) and are often accompanied by psychiatric comorbidity. Psychological flexibility (PF), characterized by the ability to adapt functionally and congruently to diverse situations based on personal values, may play a crucial role in determining HRQoL. This study aims to examine the associations between symptoms of depression, anxiety or insomnia or PF and HRQoL among individuals with PPS associated with (i) the indoor environment (IE), (ii) chronic fatigue, or (iii) both.
METHODS
We utilized the baseline data (n = 103) from a randomized controlled trial focused on improving the HRQoL of individuals (mean age 46.1, SD 7.8, 86% women) experiencing PPS associated with IE or chronic fatigue. Self-report questionnaires were administered to evaluate symptoms of depression, anxiety, insomnia, and dimensions of PF, including acceptance, cognitive fusion, and thought suppression. The primary outcome was HRQoL, assessed using a 15D questionnaire. The association between symptoms, PF dimensions, and HRQoL was examined using Pearson's correlation and ANCOVA.
RESULTS
Symptoms of depression, anxiety, and insomnia were negatively associated with HRQoL (p <.001) across all participants. Among individuals with PPS associated with IE, higher PF was significantly associated with higher HRQoL. No association was found between PF and HRQoL in those with chronic fatigue-associated PPS or both conditions.
CONCLUSIONS
PF associated with positive outcomes in HRQoL in individuals with PPS associated with the indoor environment, but not in those with chronic fatigue. Further research on the differences between these groups is warranted to enhance treatment targeting.
TRIAL REGISTRATION
Clinicaltrials.gov NCT04532827 (registered 26.08.2020).
背景
持续性躯体症状（PPS）会显著损害健康相关生活质量（HRQoL），且常伴有精神疾病共病。心理灵活性（PF）的特征是能够根据个人价值观在功能上和一致地适应各种情况，它可能在决定HRQoL方面发挥关键作用。本研究旨在探讨抑郁症、焦虑症或失眠症症状或PF与伴有（i）室内环境（IE）、（ii）慢性疲劳或（iii）两者的PPS个体的HRQoL之间的关联。
方法
我们利用了一项随机对照试验的基线数据（n = 103），该试验旨在改善患有与IE或慢性疲劳相关的PPS的个体（平均年龄46.1岁，标准差7.8，86%为女性）的HRQoL。采用自我报告问卷来评估抑郁、焦虑、失眠症状以及PF的维度，包括接纳、认知融合和思维抑制。主要结局是使用15D问卷评估的HRQoL。使用Pearson相关性分析和协方差分析来检验症状、PF维度与HRQoL之间的关联。
结果
在所有参与者中，抑郁、焦虑和失眠症状与HRQoL呈负相关（p <.001）。在与IE相关的PPS个体中，较高的PF与较高的HRQoL显著相关。在患有慢性疲劳相关PPS或两种情况都有的个体中，未发现PF与HRQoL之间存在关联。
结论
与室内环境相关的PPS个体中，PF与HRQoL的积极结果相关，但与慢性疲劳相关的PPS个体无关。有必要对这些组之间的差异进行进一步研究，以加强针对性治疗。
试验注册
Clinicaltrials.gov NCT04532827（2020年8月26日注册）。
Zotero 插件