Gaspari F, Marraro G, Penna G F, Valsecchi R, Bonati M
Eur J Clin Pharmacol. 1985;28(3):321-5. doi: 10.1007/BF00543331.
The elimination kinetics of thiopentone was studied in 7 newborns delivered by Caesarean section and in their mothers who had received the drug for induction of anaesthesia. At delivery, 4-9 min after induction, drug concentrations in cord blood were half those in material blood. The mean half-life of thiopentone in the newborns was about double that in their mothers (15 vs 7 h) confirming a disposition similar to other barbiturates. For the first time renal clearance of thiopentone was estimated in the newborn; 0.074 ml/h/kg. Only 0.0007% (about 2 micrograms) of the maternal dose was recovered in the urine of newborns over 36 h. Pentobarbitone, an active metabolite, was not detected in any specimen. The findings demonstrate the reliability of current anaesthesiological technique (thiopentone-succinylcholine-oxygen) with minimal fetal exposure to the drug.
对7例剖宫产出生的新生儿及其接受硫喷妥钠诱导麻醉的母亲进行了硫喷妥钠的消除动力学研究。分娩时，诱导后4 - 9分钟，脐血中的药物浓度是母血中的一半。新生儿中硫喷妥钠的平均半衰期约为其母亲的两倍（15小时对7小时），这证实了其处置方式与其他巴比妥类药物相似。首次估算了新生儿中硫喷妥钠的肾清除率；为0.074毫升/小时/千克。在36小时内，新生儿尿液中仅回收了母体剂量的0.0007%（约2微克）。在任何标本中均未检测到活性代谢物戊巴比妥。这些发现证明了当前麻醉技术（硫喷妥钠 - 琥珀酰胆碱 - 氧气）的可靠性，胎儿对该药物的暴露降至最低。
