Flores Raquel, Calvo Paula A, Antunes Constanca, Duarte Rodrigo, Lérias Graça
Internal Medicine, Hospital de Egas Moniz, Lisbon, PRT.
Endocrinology, Diabetes and Metabolism, Hospital de Egas Moniz, Lisbon, PRT.
Cureus. 2025 Feb 9;17(2):e78784. doi: 10.7759/cureus.78784. eCollection 2025 Feb.
is a constituent of the human intestinal microbiota, found in the commensal flora of healthy individuals. Changes in the intestinal microflora associated with chronic conditions and immunosuppression promote the bacterial translocation of . We present a case of bacteremia due to in an elderly man with multiple comorbidities, including diverticular disease and moderate SARS-CoV-2 infection requiring corticosteroid therapy. He had a prolonged hospital stay and multiple infectious complications. According to the literature review in databases such as PubMed (the last search was conducted in August 2023), a total of 17 cases were described. The reported cases had in common gastrointestinal symptoms such as gastrointestinal bleeding, diverticular disease, ulcerative colitis, cholecystitis, gastrointestinal fistula, or infection due to an orthopedic prosthesis. There was also a case in a patient with hemato-oncological disease, previously treated with a cycle of corticosteroids. It was considered that, alongside the history of diverticular disease, the immunosuppression secondary to the corticosteroid therapy for the SARS-CoV-2 infection may have contributed to the imbalance of the intestinal microbiome, leading to the occurrence of bacteremia due to this commensal agent.
是人类肠道微生物群的一个组成部分，存在于健康个体的共生菌群中。与慢性疾病和免疫抑制相关的肠道微生物群变化会促进的细菌易位。我们报告一例老年男性因导致的菌血症病例，该患者有多种合并症，包括憩室病和需要皮质类固醇治疗的中度SARS-CoV-2感染。他住院时间延长且出现多种感染并发症。根据在PubMed等数据库中的文献综述（最后一次检索于2023年8月进行），共描述了17例病例。报告的病例有共同的胃肠道症状，如胃肠道出血、憩室病、溃疡性结肠炎、胆囊炎、胃肠道瘘或因骨科假体引起的感染。还有一例血液肿瘤疾病患者，之前接受过一个周期的皮质类固醇治疗。据认为，除了憩室病病史外，SARS-CoV-2感染的皮质类固醇治疗继发的免疫抑制可能导致肠道微生物群失衡，从而导致这种共生病原体引起菌血症的发生。
