Zhang Fan, Li Wenjian
Department of Endocrinology, Changzhou Third People's Hospital, Changzhou, Jiangsu, People's Republic of China.
Department of Clinical Nutrition, Changzhou Third People's Hospital, Changzhou, Jiangsu, People's Republic of China.
Int J Womens Health. 2025 Mar 7;17:695-709. doi: 10.2147/IJWH.S516752. eCollection 2025.
This study aimed to explore the association between sarcopenia and urinary incontinence in adult women younger than 60 and provide insights into their pathophysiological mechanisms.
The study included 4,553 adult female participants aged <60, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database between 2011 and 2018. The appendicular skeletal muscle mass index (ASMI) was assessed using dual-energy X-ray absorptiometry, and sarcopenia was determined based on the resulting ASMI values (< 0.512). The type of urinary incontinence was evaluated using the Kidney Condition-Urology Questionnaire, which categorized incontinence as stress urinary incontinence, urgency urinary incontinence, or mixed urinary incontinence based on the results of the questionnaire. Multivariate adjustment models were constructed to analyze the relationship between ASMI, sarcopenia, and different types of urinary incontinence. The model incorporated a range of sociodemographic characteristics, lifestyle habits, and medical histories as covariates. Restricted cubic spline model was employed to assess the non-linear dose-response relationship between ASMI and urinary incontinence.
The results demonstrated a significant negative correlation between ASMI and the development of urinary incontinence. The risk of developing stress urinary incontinence, urgency urinary incontinence, and mixed urinary incontinence all increased significantly as ASMI decreased. The prevalence of urinary incontinence was significantly higher in patients with sarcopenia than in those without sarcopenia. Subgroup analysis demonstrated that the inverse relationship between ASMI and urinary incontinence persisted across most subgroups.
This study identifies a significant inverse association between sarcopenia and urinary incontinence in adult women under 60, emphasizing the role of muscle health in bladder function. These findings provide valuable insights for clinical risk assessment and intervention strategies.
本研究旨在探讨60岁以下成年女性肌肉减少症与尿失禁之间的关联，并深入了解其病理生理机制。
本研究纳入了4553名年龄小于60岁的成年女性参与者，利用了2011年至2018年期间美国国家健康与营养检查调查（NHANES）数据库中的数据。采用双能X线吸收法评估四肢骨骼肌质量指数（ASMI），并根据所得的ASMI值（<0.512）确定肌肉减少症。使用肾脏疾病-泌尿外科问卷评估尿失禁类型，该问卷根据问卷结果将尿失禁分为压力性尿失禁、急迫性尿失禁或混合性尿失禁。构建多变量调整模型以分析ASMI、肌肉减少症与不同类型尿失禁之间的关系。该模型纳入了一系列社会人口统计学特征、生活习惯和病史作为协变量。采用受限立方样条模型评估ASMI与尿失禁之间的非线性剂量反应关系。
结果表明ASMI与尿失禁的发生之间存在显著的负相关。随着ASMI的降低，发生压力性尿失禁、急迫性尿失禁和混合性尿失禁的风险均显著增加。肌肉减少症患者的尿失禁患病率显著高于无肌肉减少症的患者。亚组分析表明，ASMI与尿失禁之间的反向关系在大多数亚组中均持续存在。
本研究确定了60岁以下成年女性肌肉减少症与尿失禁之间存在显著的反向关联，强调了肌肉健康在膀胱功能中的作用。这些发现为临床风险评估和干预策略提供了有价值的见解。
