Noguchi T, Sugisaki T
Exp Neurol. 1985 Jul;89(1):274-8. doi: 10.1016/0014-4886(85)90284-5.
Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the Golgi-Cox method modified by Ramon-Moliner, however, the pyramidal neuron was found to have short primary dendrites with sparse branchings. This result was confirmed in sections stained for neuron-specific enolase. Therefore, we conclude that growth hormone has an independent action on neuronal development.
将生长激素基因缺陷的小鼠与正常同窝小鼠进行比较，以寻找神经元发育改变的证据。在lit/lit小鼠的运动皮层（卡维尼斯6区），细胞数量、神经元分层以及各层宽度比例与对照组（lit/+）相同。然而，用拉蒙 - 莫利纳改良的高尔基 - 考克斯方法检查发现，锥体神经元的初级树突短且分支稀疏。这一结果在神经元特异性烯醇化酶染色的切片中得到证实。因此，我们得出结论，生长激素对神经元发育具有独立作用。
