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黑真菌:一例罕见的肺毛霉病病例

The Black Fungus: A Rare Case of Pulmonary Mucormycosis.

作者信息

Wong Stephanie, Pougoue Elsa Lesley Tchouambou, Polanco Joanna, Kirimi Betty, Poonam Choudhry

机构信息

HCA Florida Northwest Hospital, Margate, Florida.

出版信息

HCA Healthc J Med. 2025 Feb 1;6(1):95-98. doi: 10.36518/2689-0216.1827. eCollection 2025.

DOI:10.36518/2689-0216.1827
PMID:40071196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11892413/
Abstract

BACKGROUND

Mucormycosis, commonly known as the "black fungus," is a severe infection affecting multiple organ systems, including the skin, brain, lungs, and gastrointestinal tract. This case report is focused on pulmonary mucormycosis, which is frequently observed in organ transplant recipients. Diagnostic challenges arise from nonspecific symptoms.

CASE PRESENTATION

Our case involved a 61-year-old male with a history of renal transplantation. The patient initially presented with a persistent cough and bloody sputum and was treated unsuccessfully for a presumed fungal infection. A lung biopsy confirmed pulmonary mucormycosis, emphasizing the heightened vulnerability of immunocompromised individuals.

CONCLUSION

This case highlights the intricate nature of mucormycosis diagnosis and management, particularly in post-organ transplantation patients. It underscores the importance of awareness and collaboration among medical specialists, including infectious disease experts, pulmonologists, and transplant teams, to optimize outcomes in the face of this life-threatening infection.

摘要

背景

毛霉病,通常被称为“黑真菌病”,是一种影响多个器官系统的严重感染,包括皮肤、大脑、肺部和胃肠道。本病例报告聚焦于肺毛霉病,这种疾病在器官移植受者中经常出现。诊断难题源于非特异性症状。

病例介绍

我们的病例是一名61岁有肾移植史的男性。患者最初表现为持续咳嗽和咯血痰,因疑似真菌感染接受治疗但未成功。肺活检确诊为肺毛霉病,凸显了免疫功能低下个体的更高易感性。

结论

本病例突出了毛霉病诊断和管理的复杂性,尤其是在器官移植后患者中。它强调了包括传染病专家、肺病学家和移植团队在内的医学专家提高认识并开展协作的重要性,以便在面对这种危及生命的感染时优化治疗结果。

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本文引用的文献

1
A Case Report of Invasive Mucormycosis in a COVID-19 Positive and Newly-Diagnosed Diabetic Patient.1例新冠病毒检测呈阳性且新诊断为糖尿病患者的侵袭性毛霉病病例报告
J Educ Teach Emerg Med. 2023 Jul 31;8(3):V10-V13. doi: 10.21980/J81M1G. eCollection 2023 Jul.
2
What Is New in Pulmonary Mucormycosis?肺毛霉病有哪些新进展?
J Fungi (Basel). 2023 Feb 28;9(3):307. doi: 10.3390/jof9030307.
3
Mucormycosis diagnosis revisited: Current and emerging diagnostic methodologies for the invasive fungal infection (Review).毛霉病诊断再探讨:侵袭性真菌感染的当前及新兴诊断方法(综述)
Exp Ther Med. 2022 Dec 5;25(1):47. doi: 10.3892/etm.2022.11746. eCollection 2023 Jan.
4
Mucormycosis: A hidden mystery of fungal infection, possible diagnosis, treatment and development of new therapeutic agents.毛霉菌病:真菌感染的隐藏谜团,可能的诊断、治疗和新治疗药物的研发。
Eur J Med Chem. 2023 Jan 15;246:115010. doi: 10.1016/j.ejmech.2022.115010. Epub 2022 Dec 10.
5
Current treatments against mucormycosis and future directions.当前针对毛霉病的治疗方法和未来方向。
PLoS Pathog. 2022 Oct 13;18(10):e1010858. doi: 10.1371/journal.ppat.1010858. eCollection 2022 Oct.
6
Mucormycosis: An opportunistic pathogen during COVID-19.毛霉菌病:COVID-19 期间的机会性病原体。
Environ Res. 2021 Oct;201:111643. doi: 10.1016/j.envres.2021.111643. Epub 2021 Jul 6.
7
Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.全球毛霉病诊断和管理指南:欧洲医学真菌学会联合会与真菌感染研究组教育和研究联盟合作开展的一项倡议。
Lancet Infect Dis. 2019 Dec;19(12):e405-e421. doi: 10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5.
8
Pulmonary mucormycosis: what is the best strategy for therapy?肺毛霉菌病:最佳治疗策略是什么?
Respir Care. 2013 May;58(5):e60-3. doi: 10.4187/respcare.02106.
9
Pulmonary mucormycosis: results of medical and surgical therapy.肺毛霉病:内科及外科治疗结果
Ann Thorac Surg. 1994 Apr;57(4):1044-50. doi: 10.1016/0003-4975(94)90243-7.