2,9-二芳基-6,13-双（三异丙基甲硅烷基乙炔基）并五苯衍生物：合成及其在癌症声动力治疗中的应用
2,9-Diaryl-6,13-bis(triisopropylsilylethynyl)pentacene derivatives: synthesis and application in cancer sonodynamic therapy.
作者信息
Han Nan, Hou Chunyuan, Duan Zhuofei, Gu Jun, Zhang Yu, Luo Jun
机构信息
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
出版信息
Chem Commun (Camb). 2025 Mar 27;61(27):5174-5177. doi: 10.1039/d5cc00326a.
PMID:40071295
Abstract
Four 2,9-aryl substituted 6,13-bis(triisopropylsilylethynyl)pentacene derivatives were synthesized as sonosensitizers. Their extensive delocalized π-electron conjugation system facilitated the generation of reactive oxygen species (ROS) under ultrasound irradiation. Therapeutic results validate that the as-prepared compounds have significant advantages in sonodynamic therapy.
摘要
合成了四种2,9-芳基取代的6,13-双（三异丙基甲硅烷基乙炔基）并五苯衍生物作为声敏剂。它们广泛的离域π电子共轭体系有助于在超声照射下产生活性氧（ROS）。治疗结果证实，所制备的化合物在声动力治疗中具有显著优势。
Zotero 插件