Han Nan, Hou Chunyuan, Duan Zhuofei, Gu Jun, Zhang Yu, Luo Jun
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Chem Commun (Camb). 2025 Mar 27;61(27):5174-5177. doi: 10.1039/d5cc00326a.
Four 2,9-aryl substituted 6,13-bis(triisopropylsilylethynyl)pentacene derivatives were synthesized as sonosensitizers. Their extensive delocalized π-electron conjugation system facilitated the generation of reactive oxygen species (ROS) under ultrasound irradiation. Therapeutic results validate that the as-prepared compounds have significant advantages in sonodynamic therapy.
合成了四种2,9-芳基取代的6,13-双（三异丙基甲硅烷基乙炔基）并五苯衍生物作为声敏剂。它们广泛的离域π电子共轭体系有助于在超声照射下产生活性氧（ROS）。治疗结果证实，所制备的化合物在声动力治疗中具有显著优势。
