含卟啉的共价有机框架的超声动力治疗合成。
Synthesis of porphyrin-incorporating covalent organic frameworks for sonodynamic therapy.
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.
出版信息
Chem Commun (Camb). 2021 Aug 25;57(66):8178-8181. doi: 10.1039/d1cc02902a. Epub 2021 Jul 27.
PMID:34318809
Abstract
Porphyrin-incorporating covalent organic frameworks were synthesized at room temperature. The resulting products with uniform morphology and excellent crystallinity exhibited good singlet oxygen generation ability. Both in vitro and in vivo experiments demonstrated the significant antitumor efficiency via sonodynamic therapy.
摘要
卟啉基金属有机框架在室温下合成。所得产物具有均匀的形态和优异的结晶度，表现出良好的单线态氧生成能力。体外和体内实验均证明了通过声动力学疗法具有显著的抗肿瘤效率。
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