Egan Allyson, Khoury Paneez
Department of Nephrology, Trinity Health Kidney Centre, Tallaght University Hospital, Dublin, Ireland.
Laboratory of Parasitic Diseases, Human Eosinophil Section, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
Rheumatology (Oxford). 2025 Mar 1;64(Supplement_1):i19-i23. doi: 10.1093/rheumatology/keaf005.
Eosinophil basic biology, including immunoregulatory functions, plays a complex role in a myriad of disorders where eosinophils play a role. Established in vivo and in vitro models and novel emerging techniques for studying eosinophils are integral to parsing the involvement of eosinophils in the pathogenesis of disorders including vasculitis. Knowledge of translational approaches from eosinophil-associated diseases and their application to eosinophilic vasculitis are highlighted. It is becoming increasingly evident that the roles of eosinophils in disease are complex. The use of targeted biological therapies and machine learning has the potential to reveal the contribution of eosinophils in disease pathology.
嗜酸性粒细胞的基础生物学，包括免疫调节功能，在嗜酸性粒细胞发挥作用的众多疾病中起着复杂的作用。用于研究嗜酸性粒细胞的成熟体内和体外模型以及新兴技术对于剖析嗜酸性粒细胞在包括血管炎在内的疾病发病机制中的作用不可或缺。文中重点介绍了从嗜酸性粒细胞相关疾病的转化方法及其在嗜酸性粒细胞性血管炎中的应用。越来越明显的是，嗜酸性粒细胞在疾病中的作用很复杂。使用靶向生物疗法和机器学习有可能揭示嗜酸性粒细胞在疾病病理中的作用。
