Tam Emily K, Ji Marco H, Fayed Alaa E, Sadek Sherin H, Ahmed Nagwa, Dihan Qais, Alzein Ahmad, Adelpour Mohsen, El Sayed Yasmine M, Elhusseiny Abdelrahman M
Department of Ophthalmology, Mary Bridge Children's Hospital, Tacoma.
Department of Pediatrics, University of Washington, Seattle, WA.
J Glaucoma. 2025 Aug 1;34(8):625-629. doi: 10.1097/IJG.0000000000002566. Epub 2025 Mar 13.
In this prospective multicenter study, eyes with primary congenital glaucoma exhibited lower retinal vascular parameters compared to healthy controls, as assessed by optical coherence tomography angiography fractal dimension analysis.
To study the retino-choroidal peripapillary microvascular pattern in primary congenital glaucoma (PCG) using fractal dimension (FD) analysis and compare it to healthy controls.
This was a prospective multicenter comparative study. We obtained peripapillary optical coherence tomography angiography (OCTA) scans (Optovue Inc) and computed FD at the vitreous/retina (large retinal vessels), inner limiting membrane/nerve fiber layer (ILM-NFL) (radial peripapillary capillary plexus, RPC), and the choroid. Other peripapillary OCTA parameters, including the whole image inside the disk and peripapillary superior and inferior vascular density (VD) parameters, were also collected. 1 eye per patient was included in the analysis.
We included a total of 17 PCG eyes and 24 control eyes. The mean age at the time of enrollment was 8.24±0.75 years in the PCG group compared to 8.33±1.09 in controls ( P =0.74). Eight patients (47%) in the PCG group and 14 (58.3%) in the control group were male. Among the PCG group, the mean vitreo-retina (large retinal vessels) FD (1.79) and ILM-NFL (RPC) FD (1.75) were significantly reduced compared to controls [vitreo-retina FD (1.85), ILM-NFL FD (1.82), P -value 0.011 and 0.014, respectively]. There was no statistically significant difference in the averaged choroidal FD between both groups (1.89 vs. 1.88, P =0.29). All optic nerve VD parameters (whole image, inside disc, superior, and inferior-hemi) were also significantly reduced in the PCG group.
PCG was associated with lower vascular parameters in the vitreo-retina (large retinal vessels) and ILM-NFL (RPC) layers as detected by OCTA FD.
在这项前瞻性多中心研究中，通过光学相干断层扫描血管造影分形维数分析评估，原发性先天性青光眼患者的眼睛与健康对照相比，视网膜血管参数较低。
使用分形维数（FD）分析研究原发性先天性青光眼（PCG）的视网膜脉络膜视乳头周围微血管模式，并与健康对照进行比较。
这是一项前瞻性多中心比较研究。我们获取了视乳头周围光学相干断层扫描血管造影（OCTA）扫描图像（Optovue公司），并计算玻璃体/视网膜（大视网膜血管）、内界膜/神经纤维层（ILM-NFL）（视乳头周围放射状毛细血管丛，RPC）和脉络膜的FD。还收集了其他视乳头周围OCTA参数，包括视盘内的全图像以及视乳头周围上、下血管密度（VD）参数。每位患者纳入1只眼睛进行分析。
我们共纳入了17只PCG眼睛和24只对照眼睛。PCG组入组时的平均年龄为8.24±0.75岁，对照组为8.33±1.09岁（P = 0.74）。PCG组8例患者（47%）为男性，对照组14例患者（58.3%）为男性。在PCG组中，玻璃体-视网膜（大视网膜血管）FD（1.79）和ILM-NFL（RPC）FD（1.75）与对照组相比显著降低[玻璃体-视网膜FD（1.85），ILM-NFL FD（1.82），P值分别为0.011和0.014]。两组之间平均脉络膜FD无统计学显著差异（1.89对1.88，P = 0.29）。PCG组所有视神经VD参数（全图像、视盘内、上方和下方半区）也显著降低。
通过OCTA FD检测发现，PCG与玻璃体-视网膜（大视网膜血管）和ILM-NFL（RPC）层中较低的血管参数相关。
