Guo Shao-Han, Xu Jian, Xu Min-Zhe, Li Chong, Gong Ya-Qin, Lu Ke
Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, No. 566 East of Qianjin Road, Suzhou, Jiangsu, 215300, China.
Department of Orthopedics, Gusu School, The First People's Hospital of Kunshan, Nanjing Medical University, Suzhou, Jiangsu, China.
Aging Clin Exp Res. 2025 Mar 13;37(1):85. doi: 10.1007/s40520-024-02917-1.
Diabetes and osteoporosis are frequent long-term conditions. There is little information on the relationship between diabetes and the risk of refracture in people who have osteoporotic fractures (OPFs), even though both conditions have been individually associated with increased fracture risk.
We conducted a retrospective cohort study using the Osteoporotic Fracture Registry System of the Affiliated Kunshan Hospital of Jiangsu University. The study included 2,255 patients aged 50 years or older who were admitted with OPFs, comprising 107 with diabetes and 2,148 without. The risk of refracture within 1, 3, and 5 years was evaluated using Cox proportional hazard regression models based on whether or not a diabetes diagnosis was made during the admission assessment. Furthermore, the rates of refracture between individuals with and without diabetes were compared using Kaplan-Meier curves.
In patients with OPFs, diabetes was significantly positively correlated with refracture risk. For the follow-up periods of 1, 3, and 5 years, the hazard ratios (HRs) in the fully adjusted model were 2.83 (95% confidence interval [CI]: 1.09 to 7.39, P-value = 0.033), 2.65 (95% CI: 1.27 to 5.52, P-value = 0.009), and 2.72 (95% CI: 1.39 to 5.32, P-value = 0.004), respectively.
The findings highlight the importance of monitoring bone health and implementing preventative interventions in individuals with diabetes, since they reveal that diabetic patients face a risk of refracture that is more than twice as high as that of non-diabetic individuals.
糖尿病和骨质疏松症是常见的长期病症。尽管这两种病症各自都与骨折风险增加相关，但关于糖尿病与骨质疏松性骨折（OPF）患者再次骨折风险之间的关系，相关信息却很少。
我们使用江苏大学附属昆山医院的骨质疏松性骨折登记系统进行了一项回顾性队列研究。该研究纳入了2255名50岁及以上因OPF入院的患者，其中107名患有糖尿病，2148名未患糖尿病。根据入院评估时是否做出糖尿病诊断，使用Cox比例风险回归模型评估1年、3年和5年内再次骨折的风险。此外，使用Kaplan-Meier曲线比较了糖尿病患者和非糖尿病患者之间的再次骨折发生率。
在OPF患者中，糖尿病与再次骨折风险显著正相关。在1年、3年和5年的随访期内，完全调整模型中的风险比（HR）分别为2.83（95%置信区间[CI]：1.09至7.39，P值 = 0.033）、2.65（95%CI：1.27至5.52，P值 = 0.009）和2.72（95%CI：1.39至5.32，P值 = 0.004）。
这些发现凸显了监测糖尿病患者骨骼健康以及实施预防性干预措施的重要性，因为它们表明糖尿病患者面临的再次骨折风险是非糖尿病患者的两倍多。
