Suoangbaji Tina, Long Renwen, Ng Irene Oi-Lin, Mak Loey Lung-Yi, Ho Daniel Wai-Hung
State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong.
Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Hong Kong.
Cancers (Basel). 2025 Mar 5;17(5):890. doi: 10.3390/cancers17050890.
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two distinct types of primary liver cancer (PLC) characterized by considerable extents of cellular and molecular heterogeneities. We recently developed a web-based cell atlas called LiverSCA that possesses a user-friendly interface and comprehensive functionalities. It facilitates the exploration of gene expression patterns, cellular compositions, and intercellular communication within the microenvironments of liver and PLC tumors.
To further enhance the documentation of data pinpointing different phenotypes/subtypes of liver and PLC, we extended the catalog of LiverSCA with additional datasets, e.g., ICC and metabolic dysfunction-associated steatotic liver disease/steatosis (MASLD/MASH).
The current enhanced version of the LiverSCA cell atlas encompasses six phenotypes (normal, HBV-HCC, HCV-HCC, non-viral HCC, ICC, and MASH), 63 patients, and over 248,000 cells. Furthermore, we have incorporated comparative visualization methods that allow users to simultaneously examine and compare gene expression levels between two different phenotypes.
We are committed to the continuous development of LiverSCA and envision that it will serve as a valuable resource to support researchers in convenient investigations into the cellular and molecular landscapes of liver and PLC.
肝细胞癌（HCC）和肝内胆管癌（ICC）是原发性肝癌（PLC）的两种不同类型，具有相当程度的细胞和分子异质性。我们最近开发了一个名为LiverSCA的基于网络的细胞图谱，它具有用户友好的界面和全面的功能。它有助于探索肝脏和PLC肿瘤微环境中的基因表达模式、细胞组成和细胞间通讯。
为了进一步加强对确定肝脏和PLC不同表型/亚型的数据的记录，我们用额外的数据集（如ICC和代谢功能障碍相关脂肪性肝病/脂肪变性（MASLD/MASH））扩展了LiverSCA的目录。
当前增强版的LiverSCA细胞图谱涵盖六种表型（正常、HBV-HCC、HCV-HCC、非病毒性HCC、ICC和MASH）、63名患者以及超过248,000个细胞。此外，我们纳入了比较可视化方法，允许用户同时检查和比较两种不同表型之间的基因表达水平。
我们致力于LiverSCA的持续开发，并设想它将成为一种有价值的资源，支持研究人员方便地研究肝脏和PLC的细胞和分子景观。
