Lee Chia-Yi, Yang Shun-Fa, Lian Ie-Bin, Chen Hung-Chi, Huang Jing-Yang, Chang Chao-Kai
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Nobel Eye Institute, Taipei 10041, Taiwan.
Diagnostics (Basel). 2025 Mar 5;15(5):634. doi: 10.3390/diagnostics15050634.
: To evaluate the postoperative outcomes between the second-generation keratorefractive lenticule extraction (KLEx) surgery and femtosecond laser in situ keratomileusis (FS-LASIK). : A retrospective cohort study was conducted and subjects received second-generation KLEx and FS-LASIK surgeries were enrolled. A total of 124 and 102 eyes were selected into the second-generation KLEx and FS-LASIK groups after exclusion. The primary outcomes were the postoperative uncorrected distance visual acuity (UDVA), spherical equivalent (SE), amount of astigmatism, and best-correct visual acuity (BCVA). The independent -test was applied to compare the primary outcomes between groups. : The mean UDVA three months postoperatively showed insignificant differences between the two groups ( = 0.999). At the final visit, there were 113 (91.12%) and 96 (94.12%) subjects who reached UDVA 20/20 in the FS-LASIK and second-generation KLEx groups and the difference was statistically insignificant ( = 0.455), and the second-generation KLEx group illustrated a higher UDVA improvement ( = 0.046). The SE three months postoperatively showed insignificant difference between groups, whether the absolute value or the ratio of SE within ±0.50 D or ±1.00 D (all > 0.05). The vector analysis indicated that the difference vector (DV) was significantly lower in the second-generation KLEx group ( = 0.033). The ratio of loss of more than 1 line BCVA showed insignificant differences between the two groups (all > 0.05). In addition, the risk of postoperative dry eye disease (DED) was significantly higher in the FS-LASIK group ( = 0.031). : The efficiency and predictability between second-generation KLEx and FS-LASIK surgeries are similar, while more DED occurred after FS-LASIK surgery.
评估第二代角膜屈光透镜切除术（KLEx）与飞秒激光原位角膜磨镶术（FS-LASIK）的术后效果。：进行了一项回顾性队列研究，纳入接受第二代KLEx和FS-LASIK手术的受试者。排除后，分别有124只眼和102只眼被选入第二代KLEx组和FS-LASIK组。主要观察指标为术后裸眼远视力（UDVA）、等效球镜度（SE）、散光量和最佳矫正视力（BCVA）。采用独立样本t检验比较两组的主要观察指标。：术后三个月时，两组的平均UDVA差异无统计学意义（P = 0.999）。末次随访时，FS-LASIK组和第二代KLEx组分别有113例（91.12%）和96例（94.12%）受试者达到UDVA 20/20，差异无统计学意义（P = 0.455），且第二代KLEx组的UDVA改善程度更高（P = 0.046）。术后三个月时，无论SE的绝对值还是在±0.50 D或±1.00 D范围内的SE比值，两组间差异均无统计学意义（均P > 0.05）。矢量分析表明，第二代KLEx组的差异矢量（DV）显著更低（P = 0.033）。两组BCVA下降超过1行的比例差异无统计学意义（均P > 0.05）。此外，FS-LASIK组术后干眼疾病（DED）的风险显著更高（P = 0.031）。：第二代KLEx与FS-LASIK手术的有效性和可预测性相似，但FS-LASIK术后发生更多DED。
