Welch W R, Robboy S J, Kaufman R H, Townsend D, Noller K L, Gundersen J, Lawrence W D, Richart R M, O'Brien P, McGorray S
Gynecol Oncol. 1985 Jul;21(3):277-86. doi: 10.1016/0090-8258(85)90264-1.
An analysis of 6055 colposcopically directed biopsy specimens from 2635 diethylstilbestrol (DES)-exposed women and 445 biopsy specimens from 277 nonexposed women was undertaken to correlate microscopic findings with colposcopic patterns. All examinations were performed using a standardized protocol which required that each participant have colposcopy, cytologic smears, and biopsy of abnormal colposcopic lesions. The findings of colposcopic "columnar epithelium, gland openings, and Nabothian cysts" correlated most often with glandular epithelium in the biopsy specimen. "White epithelium," which includes three related colposcopic patterns, mosaicism, punctation, and white epithelium, was associated most frequently (82-93% of cases) with squamous metaplasia, but occasionally with dysplasia and carcinoma in situ (CIS)(0-6%). The presence of dysplasia or CIS in any individual biopsy specimen occurred most frequently with the observation of higher graded lesions by colposcopy or a prior diagnosis of dysplasia.
对2635名曾接触己烯雌酚（DES）的女性的6055份阴道镜引导下活检标本以及277名未接触者的445份活检标本进行分析，以将微观发现与阴道镜检查模式相关联。所有检查均按照标准化方案进行，该方案要求每位参与者都要进行阴道镜检查、细胞学涂片以及对异常阴道镜病变进行活检。阴道镜检查发现的“柱状上皮、腺开口和纳博特囊肿”在活检标本中最常与腺上皮相关。“白色上皮”包括三种相关的阴道镜检查模式，即镶嵌、点状和白色上皮，最常（82%-93%的病例）与鳞状化生相关，但偶尔也与发育异常和原位癌（CIS）相关（0%-6%）。在任何单个活检标本中出现发育异常或CIS最常与阴道镜检查发现更高分级的病变或先前诊断为发育异常有关。
