Letonja Jernej, Nussdorfer Petra, Petrovič Danijel
Laboratory for Histology and Genetics of Atherosclerosis and Microvascular Diseases, Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.
Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.
Int J Mol Sci. 2025 Feb 20;26(5):1832. doi: 10.3390/ijms26051832.
Diabetic nephropathy (DN) is a microvascular complication of type 2 diabetes mellitus (T2DM) that develops after years of T2DM and affects approximately one in four diabetic patients. Thioredoxin (TXN), thioredoxin reductase (TXNRD), and thioredoxin-interacting protein (TXNIP) are part of the thioredoxin antioxidant system, which is involved in DN. We included 897 Slovenian patients with T2DM lasting more than 10 years in our preliminary study. In total, 344 patients with DN were included in our case group, while 553 without DN comprised our control group. The genotypes of rs8140110, rs1548357, and rs7212 were determined for all participants using real-time PCR. We found a statistically significant association between the T allele of the rs8140110 polymorphism and DN ( < 0.001; OR: 0.52; 95% CI: 0.36-0.74). The TT and TC genotypes were also significantly less likely to develop DN in comparison to the CC genotype according to the dominant model of inheritance ( < 0.001; OR: 0.51; 95 CI: 0.34-0.75). We did not find a statistically significant association between rs1548357 or rs7212 and DN. To conclude, the rs8140110 polymorphism in the TXN2 gene is associated with DN in Slovenian patients with T2DM.
糖尿病肾病（DN）是2型糖尿病（T2DM）的一种微血管并发症，在患T2DM数年之后出现，约四分之一的糖尿病患者会受其影响。硫氧还蛋白（TXN）、硫氧还蛋白还原酶（TXNRD）和硫氧还蛋白相互作用蛋白（TXNIP）是硫氧还蛋白抗氧化系统的组成部分，该系统与糖尿病肾病有关。在我们的初步研究中纳入了897名病程超过10年的斯洛文尼亚T2DM患者。我们的病例组共纳入了344例DN患者，而553例无DN患者组成了我们的对照组。使用实时聚合酶链反应确定了所有参与者的rs8140110、rs1548357和rs7212基因型。我们发现rs8140110多态性的T等位基因与DN之间存在统计学显著关联（P<0.001；比值比：0.52；95%置信区间：0.36 - 0.74）。根据显性遗传模式，与CC基因型相比，TT和TC基因型发生DN的可能性也显著降低（P<0.001；比值比：0.51；95%置信区间：0.34 - 0.75）。我们未发现rs1548357或rs721还与DN之间存在统计学显著关联。总之，TXN2基因中的rs8140110多态性与斯洛文尼亚T2DM患者的DN有关。
