Arul Arasan Tamil Selvan, Jorgensen Rick, Van Antwerp Chris, Ng Perry K W, Gangur Venu
Food Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.
Cereal Science Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.
Foods. 2025 Mar 5;14(5):883. doi: 10.3390/foods14050883.
Wheat is a staple and nutritious food that is consumed globally. However, it is identified as a major allergenic food because of its capacity to trigger life-threatening systemic anaphylaxis. The specific mechanisms that underlie this systemic anaphylaxis in wheat allergy are incompletely understood. As a result, several rodent models have been developed to study anaphylaxis in wheat allergies. In this paper, we have conducted a comprehensive review of wheat-induced anaphylaxis using Google Scholar and PubMed databases with relevant keywords. The following objectives were addressed: (1) to determine the complexity of wheat-induced anaphylaxis; (2) to summarize the role of genetic susceptibility in wheat anaphylaxis; (3) to identify the environmental factors involved in the development of wheat anaphylaxis; (4) to map the current status of mechanisms involved in wheat anaphylaxis; (5) to identify the approaches, strengths, and limitations of rodent models of wheat anaphylaxis; and (6) to identify challenges and opportunities in this area of science. Our findings provide a comprehensive updated critical resource for the future research agenda in wheat allergy-associated anaphylaxis, particularly using rodent models as attractive pre-clinical tools.
小麦是一种全球范围内食用的主食和营养食品。然而，由于其引发危及生命的全身性过敏反应的能力，它被认定为一种主要的致敏食物。小麦过敏中这种全身性过敏反应的具体机制尚未完全明确。因此，已经开发了几种啮齿动物模型来研究小麦过敏中的过敏反应。在本文中，我们使用谷歌学术和PubMed数据库，通过相关关键词对小麦诱发的过敏反应进行了全面综述。探讨了以下目标：（1）确定小麦诱发过敏反应的复杂性；（2）总结遗传易感性在小麦过敏反应中的作用；（3）确定参与小麦过敏反应发生的环境因素；（4）梳理小麦过敏反应相关机制的现状；（5）确定小麦过敏反应啮齿动物模型的方法、优势和局限性；（6）确定该科学领域的挑战和机遇。我们的研究结果为小麦过敏相关过敏反应的未来研究议程提供了一份全面更新的重要资源，特别是将啮齿动物模型作为有吸引力的临床前工具。
