Oh Joon-Kyung, Kim Jae-Hyeong, An Ga-Eul-Hae, Chang Hee-Ra
Department of Pharmaceutical Engineering, Graduate School, Hoseo University, Asan 31499, Republic of Korea.
Foods. 2025 Mar 6;14(5):904. doi: 10.3390/foods14050904.
The use of pesticides is essential for the production of high-quality agricultural products. However, the repeated application of pesticides has led to the contamination of environments, such as the atmosphere, soil, and surface water, affecting ecosystems and leading to residues on crops, which pose potential risks to human health. Accordingly, regulations regarding pesticide usage, application frequency, timing, and maximum residue limits have been established to manage residual pesticides. The Positive List System (PLS), with a default tolerance of 0.01 ppm, has been applied to both domestic and imported agricultural products for which no established maximum residue limits (MRLs) exist in Korea. This study developed a multi-residue analytical method for the simultaneous determination of six pesticides, including 2,4-DB and 2,4,5-T, for which no domestic MRLs have been established, as well as for 2,4-D, 4-CPA, Dicamba, and Dichlorprop, for the management of imported agricultural products. The target pesticides were extracted and purified using the QuEChERS method and quantified by LC-MS/MS. The analytical method was validated according to the CODEX (CAC/GL 40-1993) and the Guidelines of Standard Procedures of Test Methods for Foods and Other Substances established by the MFDS. Using the developed and validated analytical method, monitoring of imported agricultural products was conducted.
农药的使用对于高质量农产品的生产至关重要。然而，农药的反复施用导致了大气、土壤和地表水等环境的污染，影响了生态系统，并导致农作物上有残留，这对人类健康构成潜在风险。因此，已制定了有关农药使用、施用频率、施用时间和最大残留限量的规定，以管理残留农药。韩国对国内和进口的、在韩国没有既定最大残留限量（MRL）的农产品采用了默认容忍度为0.01 ppm的肯定列表制度（PLS）。本研究开发了一种多残留分析方法，用于同时测定六种农药，包括在韩国没有既定国内MRL的2,4-滴丁酸和2,4,5-涕，以及用于管理进口农产品的2,4-滴、对氯苯氧乙酸、麦草畏和二氯丙酸。目标农药采用QuEChERS方法进行提取和净化，并通过液相色谱-串联质谱法进行定量。该分析方法根据食品法典委员会（CAC/GL 40-1993）以及韩国食品药品安全部制定的食品及其他物质检测方法标准程序指南进行了验证。使用所开发和验证的分析方法，对进口农产品进行了监测。
