Lehtola J, Karttunen T, Krekelä I, Niemelä S, Räsänen O
Hepatogastroenterology. 1985 Apr;32(2):72-6.
In a series of 44 patients with pernicious anemia examined by gastroscopy, three cases of gastric carcinoids were found. During the same ten-year period about 11,000 gastroscopies were performed on patients not suffering from pernicious anemia, and only one case of gastric carcinoid was detected. In two of the cases no endoscopic lesion was seen and the carcinoid was detectable only at histological examination, while in one case an unusual combination of carcinoid tumor and tubular adenoma in the same polyp was found. Most of the carcinoids arose in atrophic body mucosa, but in one case the mucosa around the carcinoid showed antral properties. One patient had slightly elevated values of pancreatic polypeptide, while no hormonal activity was found in others. No growth or spread of the carcinoid was observed during follow-up. It is suggested that the same pathogenetic factors may operate in the genesis of gastric carcinoid and gastric carcinoma in patients with pernicious anemia.
在对44例恶性贫血患者进行胃镜检查的系列病例中，发现了3例胃类癌。在同一十年期间，对非恶性贫血患者进行了约11,000次胃镜检查，仅检测到1例胃类癌。其中2例未发现内镜下病变，仅在组织学检查时可检测到类癌，而在1例中，同一息肉内发现类癌肿瘤与管状腺瘤的异常组合。大多数类癌发生于萎缩性胃体黏膜，但在1例中，类癌周围的黏膜显示出胃窦的特征。1例患者的胰多肽值略有升高，而其他患者未发现激素活性。随访期间未观察到类癌生长或扩散。提示在恶性贫血患者中，相同的致病因素可能在胃类癌和胃癌的发生中起作用。
