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孕产妇贫血作为儿童贫血的预测指标:来自冈比亚健康数据的证据。

Maternal Anemia as a Predictor of Childhood Anemia: Evidence from Gambian Health Data.

作者信息

Sowe Alhagie, Wood Elizabeth, Gautam Santosh Kumar

机构信息

Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.

Keough School of Global Affairs, University of Notre Dame, Notre Dame, IN 46556, USA.

出版信息

Nutrients. 2025 Feb 28;17(5):879. doi: 10.3390/nu17050879.

Abstract

BACKGROUND

Iron deficiency anemia (IDA) is a significant global health problem affecting close to 2 billion people worldwide. The prevalence of IDA is higher among children younger than five years and women of reproductive age, indicating an intergenerational correlation between maternal and child anemia. This study aims to analyze the association between maternal and child anemia in The Gambia.

METHODS

A nationally representative dataset comprising 3249 children under the age of five, obtained from The Gambia Demographic and Health Survey (2019-2020), was utilized for empirical analyses. Multivariate linear regression models were employed to assess the association between maternal and child anemia. The multivariate models were adjusted for various confounding variables, including birth order, age, and the gender of the child, as well as maternal education, religion, wealth quintiles, rural residence, and region-fixed effects.

RESULTS

Fifty-three percent of children and 52% of mothers are anemic. Children from poorer households show a higher rate of anemia compared to those from wealthier households. Maternal anemia was significantly associated with the anemia status of the children. Children born to anemic mothers were 13.5% more likely to be also anemic ( < 0.001). The correlation coefficient between mother and child hemoglobin levels is 0.165 ( < 0.001). The correlation coefficient between maternal and child anemia is higher among the bottom three wealth quintiles than the top two wealth quintiles.

CONCLUSIONS

The significant intergenerational association between maternal and child anemia status highlights the need for targeted, multi-pronged strategies to combat the adverse impacts of anemia. Maternal anemia, in general, appears to influence childhood anemia beyond just the pregnancy period. Shared socioeconomic environment, dietary patterns, and exposure to infections likely contribute to this intergenerational association.

摘要

背景

缺铁性贫血(IDA)是一个重大的全球健康问题,全球近20亿人受其影响。五岁以下儿童和育龄妇女中缺铁性贫血的患病率更高,这表明母婴贫血之间存在代际关联。本研究旨在分析冈比亚母婴贫血之间的关联。

方法

利用从冈比亚人口与健康调查(2019 - 2020年)获得的一个具有全国代表性的数据集,其中包括3249名五岁以下儿童,进行实证分析。采用多元线性回归模型来评估母婴贫血之间的关联。多元模型针对各种混杂变量进行了调整,包括出生顺序、年龄、孩子性别,以及母亲的教育程度、宗教信仰、财富五分位数、农村居住情况和地区固定效应。

结果

53%的儿童和52%的母亲贫血。与富裕家庭的儿童相比,贫困家庭的儿童贫血率更高。母亲贫血与孩子的贫血状况显著相关。贫血母亲所生的孩子贫血的可能性要高13.5%(<0.001)。母婴血红蛋白水平的相关系数为0.165(<0.001)。在最贫困的三个财富五分位数中,母婴贫血的相关系数高于最富裕的两个财富五分位数。

结论

母婴贫血状况之间显著的代际关联凸显了采取有针对性的多管齐下策略来应对贫血不利影响的必要性。一般来说,母亲贫血似乎不仅在孕期影响儿童贫血。共同的社会经济环境、饮食模式和感染暴露可能导致了这种代际关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f532/11901893/20352d3bdc42/nutrients-17-00879-g001.jpg

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