鼠伤寒沙门氏菌和大肠杆菌中核糖核酸聚合酶rpoB顺反子突变对DnaA表型的抑制作用。
Suppression of the DnaA phenotype by mutations in the rpoB cistron of ribonucleic acid polymerase in Salmonella typhimurium and Escherichia coli.
作者信息
Bagdasarian M M, Izakowska M, Bagdasarian M
出版信息
J Bacteriol. 1977 May;130(2):577-82. doi: 10.1128/jb.130.2.577-582.1977.
Abstract
A class of mutations that confer resistance to rifampin in Salmonella typhimurium and Escherichia coli also suppresses the thermosensitivity of chromosome initiation in dnaA mutants. Ribonucleic acid polymerase is resistant to rifampin in vitro in these suppressive mutants, and the suppressors of dnaA cannot be separated from the rpoB mutations by transduction. It is concluded, therefore, that certain rpoB mutations may suppress the DnaA phenotype.
摘要
一类使鼠伤寒沙门氏菌和大肠杆菌对利福平产生抗性的突变，也能抑制dnaA突变体中染色体起始的温度敏感性。在这些抑制性突变体中，核糖核酸聚合酶在体外对利福平具有抗性，并且dnaA的抑制子不能通过转导与rpoB突变分离。因此得出结论，某些rpoB突变可能抑制DnaA表型。
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