Chen Jing, Fan Yanzi, Jia Xize, Fan Fengmei, Wang Jinhui, Zou Qihong, Chen Bing, Che Xianwei, Lv Yating
Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, 311121, China.
Institute of Psychological Science, Hangzhou Normal University, Hangzhou, 311121, China.
Neurosci Bull. 2025 May;41(5):837-852. doi: 10.1007/s12264-025-01375-7. Epub 2025 Mar 13.
Attempts have been made to modulate motor sequence learning (MSL) through repetitive transcranial magnetic stimulation, targeting different sites within the sensorimotor network. However, the target with the optimum modulatory effect on neural plasticity associated with MSL remains unclarified. This study was therefore designed to compare the role of the left primary motor cortex and the left supplementary motor area proper (SMAp) in modulating MSL across different complexity levels and for both hands, as well as the associated neuroplasticity by applying intermittent theta burst stimulation together with the electroencephalogram and concurrent transcranial magnetic stimulation. Our data demonstrated the role of SMAp stimulation in modulating neural communication to support MSL, which is achieved by facilitating regional activation and orchestrating neural coupling across distributed brain regions, particularly in interhemispheric connections. These findings may have important clinical implications, particularly for motor rehabilitation in populations such as post-stroke patients.
人们已经尝试通过重复经颅磁刺激来调节运动序列学习（MSL），靶点为感觉运动网络内的不同部位。然而，对与MSL相关的神经可塑性具有最佳调节作用的靶点仍不明确。因此，本研究旨在比较左侧初级运动皮层和左侧辅助运动区固有部（SMAp）在调节不同复杂程度和双手的MSL中的作用，以及通过应用间歇性θ波爆发刺激结合脑电图和同步经颅磁刺激来比较相关的神经可塑性。我们的数据证明了SMAp刺激在调节神经通讯以支持MSL中的作用，这是通过促进区域激活和协调分布在不同脑区的神经耦合来实现的，特别是在半球间连接中。这些发现可能具有重要的临床意义，尤其是对中风后患者等人群的运动康复。
