Davey P, Gozzard D, Goodall M, Leyland M J
J Antimicrob Chemother. 1985 May;15(5):623-8. doi: 10.1093/jac/15.5.623.
Hypomagnesaemia occurred in 6 of 11 leukaemic patients who received gentamicin. This problem has been reported relatively infrequently when gentamicin is used alone. Our hypomagnesaemic patients received concurrent courses of gentamicin with cytotoxic therapy significantly more often but it is not clear whether this represents a true drug interaction or an interaction between gentamicin and the products of cell lysis produced by cytotoxic treatment. The incidence of this problem has been underestimated previously because hypocalcaemia was used as an indicator. Renal wasting of magnesium is well documented as the mechanism by which the hypomagnesaemia is sustained but further investigation is required to see whether other factors are involved in its initiation.
11名接受庆大霉素治疗的白血病患者中有6人出现了低镁血症。单独使用庆大霉素时，这个问题的报道相对较少。我们的低镁血症患者同时接受庆大霉素和细胞毒性治疗的疗程明显更多，但尚不清楚这是真正的药物相互作用，还是庆大霉素与细胞毒性治疗产生的细胞裂解产物之间的相互作用。此前这个问题的发生率被低估了，因为低钙血症被用作一个指标。镁的肾性流失是低镁血症持续存在的机制，这一点已有充分记录，但还需要进一步研究，以确定是否有其他因素参与其发病过程。
