Albrecht Carolin, Graw Kathrin, Kehl Victoria, Hostettler Isabel, Meyer Bernhard, Matzarakis Andreas, Wostrack Maria
Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Human Biometeorology Unit, Center for Medical Meteorological Research, German Meteorological Service, Freiburg, Germany.
Int J Biometeorol. 2025 Jun;69(6):1267-1277. doi: 10.1007/s00484-025-02890-y. Epub 2025 Mar 14.
Controversy surrounds seasonal variations in aneurysmal subarachnoid hemorrhage (aSAH) incidence and course. Investigating weather effects associated with weather fronts may provide more insights. Meteorological parameters are grouped into classes describing biotropic weather conditions influencing human health. Known as bio-synop classes, they impact human health by influencing biological processes. Our study explores the relationship between these classes and aSAH occurrence and severity using data from our neurovascular center and the German national weather registry. Data from 605 aSAH patients treated between 2006 and 2021 was analyzed. The Kruskal-Wallis Test was used to assess the incidence and severity of aSAH, classified by Hunt&Hess (HH) grades across bio-synop classes. Additionally, we explored seasonal clustering of aSAH events. While no significant difference in ASAH incidence across specific bio-synop classes was observed (p = 0.165), class 4 "Low-pressure with cold air advection" was significantly associated with a higher incidence of poorer HH grades (p = 0.022). Further, we observed a decrease in aSAH cases in June in month-to-month comparisons (May vs. June p < 0.001). Although bio-synop classes may not directly affect aSAH incidence, they appear linked to aSAH severity. The reduction in June aSAH cases suggests a potential seasonal influence, indicating a complex interplay of environmental factors warranting further investigation.
动脉瘤性蛛网膜下腔出血（aSAH）的发病率和病程的季节性变化存在争议。研究与锋面相关的天气影响可能会提供更多见解。气象参数被归类为描述影响人类健康的生物性天气状况的类别。它们被称为生物天气学类别，通过影响生物过程来影响人类健康。我们的研究利用我们神经血管中心和德国国家气象登记处的数据，探讨了这些类别与aSAH发生和严重程度之间的关系。分析了2006年至2021年期间接受治疗的605例aSAH患者的数据。使用Kruskal-Wallis检验评估aSAH的发病率和严重程度，根据生物天气学类别按Hunt&Hess（HH）分级进行分类。此外，我们还探讨了aSAH事件的季节性聚集情况。虽然在特定生物天气学类别中未观察到aSAH发病率的显著差异（p = 0.165），但第4类“伴有冷空气平流的低压”与较差HH分级的较高发病率显著相关（p = 0.022）。此外，在逐月比较中，我们观察到6月份aSAH病例有所减少（5月与6月，p < 0.001）。虽然生物天气学类别可能不会直接影响aSAH发病率，但它们似乎与aSAH严重程度有关。6月份aSAH病例的减少表明存在潜在的季节性影响，这表明环境因素之间存在复杂的相互作用，值得进一步研究。
