Hattori T
J Clin Pathol. 1985 Jun;38(6):622-30. doi: 10.1136/jcp.38.6.622.
A morphological range of 67 hyperplastic polyps was studied. They included polyps removed endoscopically and polyps found incidentally in resected stomachs with gastric ulcers and cancer. The hyperplastic polyps were essentially composed of cystic foveolae and pyloric type glands, lined by cells identical to those of the normal gastric mucosa. Thirty one polyps contained other cytological elements. In 18, intestinal metaplasia was seen; the tubules were mostly composed of columnar and goblet cells and lacked Paneth cells. In 11 polyps, nine cases of gastric dysplasia and two cases of intestinal dysplasia, dysplastic changes were found. The former consisted of a proliferation of irregularly shaped pits with pleomorphic cuboidal/columnar cells with relatively basophilic cytoplasm. They contained mucigen granules of a gastric type. The latter consisted of atypical pits composed of closely packed, tall columnar and small goblet cells, both resembling adenomatous cells of the colon. In three polyps carcinomas were seen, one of which was an intestinal type adenocarcinoma. In the other two, the cancer cells closely resembled the normal foveolar cells, containing gastric type mucigen granules. They were gastric type adenocarcinomas.
对67个增生性息肉的形态学范围进行了研究。它们包括经内镜切除的息肉以及在伴有胃溃疡和癌症的切除胃中偶然发现的息肉。增生性息肉主要由囊性小凹和幽门型腺体组成，内衬细胞与正常胃黏膜细胞相同。31个息肉含有其他细胞学成分。18个息肉可见肠化生；小管大多由柱状细胞和杯状细胞组成，缺乏潘氏细胞。在11个息肉中，发现9例胃发育异常和2例肠发育异常。前者由形状不规则的小凹增生组成，小凹内有异形的立方/柱状细胞，细胞质相对嗜碱性。它们含有胃型黏液原颗粒。后者由非典型小凹组成，小凹由紧密排列的高柱状细胞和小杯状细胞组成，两者都类似于结肠腺瘤细胞。在3个息肉中发现了癌，其中1个是肠型腺癌。另外2个中，癌细胞与正常小凹细胞非常相似，含有胃型黏液原颗粒。它们是胃型腺癌。
