Kamiya T, Morishita T, Asakura H, Munakata Y, Miura S, Tsuchiya M
Am J Gastroenterol. 1981 Apr;75(4):275-81.
In a series of 2,013 gastric polyps in 1,201 patients, morphological and histopathological studies have been performed. Ninety-three hyperplastic polyps in 56 patients have been followed-up endoscopically and histopathologically for five to 12 years. The incidence of detection of gastric polyps has increased: 1.4% in 1967 to 8.7% in 1979 year by year. Thirty patients (54%) among the 56 showed changes in number, size or shape of polyps during follow-up. Twenty patients (37%) revealed numerical changes (increase in 16 patients, reversion in three patients and vanishing in two patients). Twenty-eight polyps (30%) showed morphological changes, six of them showed continuous enlargement, 18 lesions repeated enlargement, stationary or reduction stages, three lesions were reversed and two polyps disappeared. Histopathologically, three lesions showed transformation from the hyperplastic type to adenoma while demonstrating morphological enlargement. Two of these showed increase in cellular atypia, from the hyperplastic type through adenoma with severe atypia and finally to carcinoma in the polypectomy specimens. From this study, it was concluded that although hyperplastic polyps show changes in size, shape or number with passage of time, malignant changes occur in only a few cases.
对1201例患者的2013个胃息肉进行了形态学和组织病理学研究。对56例患者的93个增生性息肉进行了5至12年的内镜和组织病理学随访。胃息肉的检出率逐年上升：1967年为1.4%，1979年为8.7%。56例患者中有30例（54%）在随访期间息肉数量、大小或形态发生了变化。20例（37%）出现数量变化（16例增加，3例逆转，2例消失）。28个息肉（30%）出现形态学变化，其中6个持续增大，18个病变反复出现增大、静止或缩小阶段，3个病变逆转，2个息肉消失。组织病理学上，3个病变在形态学增大的同时显示从增生型向腺瘤转变。其中2个在息肉切除标本中显示细胞异型性增加，从增生型经重度异型性腺瘤最终发展为癌。从这项研究得出的结论是，虽然增生性息肉会随时间推移出现大小、形状或数量的变化，但只有少数病例会发生恶性变化。
