Kitaigorodsky Marcela, Crocco Elizabeth, Curiel-Cid Rosie E, Leal Giselle, Zheng Diane, Eustache Melissa K, Greig-Custo Maria T, Barker William, Duara Ranjan, Loewenstein David A
Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.
1Florida Alzheimer's Disease Research Center Gainesville Florida USA.
Alzheimers Dement (Amst). 2021 May 25;13(1):e12192. doi: 10.1002/dad2.12192. eCollection 2021.
There is increasing evidence that susceptibility to proactive semantic interference (PSI) and the failure to recover from PSI (frPSI) as evidenced by intrusion errors may be early cognitive markers of both preclinical and prodromal Alzheimer's disease (AD).
One hundred forty-five participants were administered extensive clinical and neuropsychological evaluations including the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), a sensitive cognitive stress test measuring PSI and frPSI. Participants also underwent structural magnetic resonance imaging (MRI) and amyloid positron emission tomography/computed tomography (PET/CT) imaging.
PSI and frPSI errors were much more prevalent in the mild cognitive impairment (MCI)-AD (amyloid positive) group than the other diagnostic groups. The number of intrusion errors observed across the other MCI groups without amyloid pathology and those with normal cognition were comparable.
Semantic intrusion errors on the LASSI-L occur much less frequently in persons who have different types of non-AD-related MCI and may be used as an early cognitive marker of prodromal AD.
越来越多的证据表明，主动语义干扰（PSI）易感性以及如侵入性错误所证明的无法从PSI中恢复（frPSI），可能是临床前和前驱期阿尔茨海默病（AD）的早期认知标志物。
145名参与者接受了广泛的临床和神经心理学评估，包括用于语义干扰和学习的洛温斯坦 - 阿塞维多量表（LASSI-L），这是一项测量PSI和frPSI的敏感认知应激测试。参与者还接受了结构磁共振成像（MRI）和淀粉样蛋白正电子发射断层扫描/计算机断层扫描（PET/CT）成像。
与其他诊断组相比，轻度认知障碍（MCI）-AD（淀粉样蛋白阳性）组中的PSI和frPSI错误更为普遍。在其他无淀粉样蛋白病理学的MCI组和认知正常的组中观察到的侵入性错误数量相当。
LASSI-L上的语义侵入性错误在患有不同类型非AD相关MCI的人群中发生频率要低得多，并且可以用作前驱期AD的早期认知标志物。
