Persel Cristiane, da Silva Jessica Cassia, Simon Caroline, Delabeneta Mateus Foltz, Boff Junges Daniele Schaab, Nascimento Bruna Larissa, Flores Chaves Michele Ana, Simão Rita de Cássia Garcia, Paula Claudete Rodrigues, Gandra Rinaldo Ferreira
Department of Pharmacy, University Hospital from Western Paraná State University, at 3224, Tancredo Neves Avenue, Cascavel City, Paraná 85806-470, Brazil.
Faculty of Dentistry, Department of Stomatology, University of São Paulo, São Paulo, São Paulo, Brazil.
Water Sci Technol. 2025 Mar;91(5):581-591. doi: 10.2166/wst.2025.028. Epub 2025 Feb 26.
is a yeast-producing mycocins and has antimicrobial action. is the predominant bacterium of the coliforms group; its presence in water indicates fecal contamination, being used as an indicator of microbiological analyses. The immobilization of cells and substances demonstrates great potential for biotechnological applications. This work aimed to assess the activity of free and immobilized mycocins, obtained from , against strains and fecal coliforms. The mycocins were immobilized in different concentrations of sodium alginate and calcium chloride and tested to verify the antimicrobial activity against the strain and fecal coliforms present in water samples. The mycocins were able to inhibit all strains used in broth microdilution. Considering the problem of multidrug-resistant antibiotic strains and the need for new alternatives to improve the quality of water and sewage effluents, these results demonstrate a possible application as an alternative to an antimicrobial agent.
是一种产生酵母素且具有抗菌作用的酵母菌。是大肠菌群中的主要细菌；其在水中的存在表明粪便污染，被用作微生物分析的指标。细胞和物质的固定化在生物技术应用中显示出巨大潜力。这项工作旨在评估从 获得的游离和固定化酵母素对 菌株和粪大肠菌群的活性。将酵母素固定在不同浓度的海藻酸钠和氯化钙中，并进行测试以验证对水样中 菌株和粪大肠菌群的抗菌活性。酵母素能够抑制肉汤微量稀释中使用的所有菌株。考虑到多重耐药抗生素菌株的问题以及需要新的替代方法来提高水和污水的质量，这些结果表明作为抗菌剂的替代品具有可能的应用。
