Brasher Trey, Rosen David, Spinella Marcello
Pharmacology and Toxicology Graduate Group, University of California, Davis, USA.
Psychedelics and Consciousness Research Center, Johns Hopkins University, Baltimore, Maryland, USA.
J Psychoactive Drugs. 2025 Mar 15:1-14. doi: 10.1080/02791072.2025.2474244.
Recent clinical trials on classic psychedelics for depression and anxiety have raised questions about their potential to treat other psychiatric conditions. Evidence from pre-clinical and clinical research suggests psychedelics may help with substance use disorders, with ongoing registered trials. Behavioral addictions, sharing features with substance addictions, may also respond to psychedelic treatment. This study examined self-reported symptoms of problem gambling, sexual addiction, compulsive buying, and eating disorders in a community sample ( = 1107), alongside measures of well-being (self-transcendence, personal growth, depression/anxiety, etc.), and use of psychedelics and other psychoactive drugs. Significant positive correlations emerged among well-being measures and among behavioral addiction symptoms, with inverse correlations between well-being and behavioral addictions. Psychedelic users reported greater well-being and lower behavioral addiction symptoms, even after controlling for demographics and other drug use. Principal components analysis showed that behavioral addictions formed a single factor, which was combined into a composite score. Multiple regression analyses revealed that major stimulant, alcohol, and nicotine vaping use predicted higher behavioral addiction scores, while psychedelic use uniquely predicted lower scores. These findings suggest psychedelics may aid in treating behavioral addictions. A controlled pilot study or clinical trial is warranted to explore this therapeutic potential further.
近期关于经典致幻剂治疗抑郁症和焦虑症的临床试验引发了人们对其治疗其他精神疾病潜力的质疑。临床前和临床研究的证据表明,致幻剂可能有助于治疗物质使用障碍,目前有正在进行的注册试验。行为成瘾与物质成瘾有共同特征,也可能对致幻剂治疗有反应。本研究调查了一个社区样本(n = 1107)中自我报告的问题赌博、性成瘾、强迫性购物和饮食失调症状,同时测量了幸福感(自我超越、个人成长、抑郁/焦虑等)以及致幻剂和其他精神活性药物的使用情况。幸福感测量指标之间以及行为成瘾症状之间出现了显著的正相关,而幸福感与行为成瘾之间呈负相关。即使在控制了人口统计学因素和其他药物使用情况后,使用致幻剂的人报告的幸福感更高,行为成瘾症状更低。主成分分析表明,行为成瘾形成了一个单一因素,并合并为一个综合得分。多元回归分析显示,主要兴奋剂、酒精和尼古丁电子烟的使用预测了更高的行为成瘾得分,而致幻剂的使用则独特地预测了更低的得分。这些发现表明,致幻剂可能有助于治疗行为成瘾。有必要进行一项对照试验性研究或临床试验,以进一步探索这种治疗潜力。