Ulisse Krista, Albitar Jehad, Aromin Jourdan T, Berry James
Department of Behavioral Medicine and Psychiatry, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
Brain Sci. 2025 Sep 12;15(9):980. doi: 10.3390/brainsci15090980.
Addiction remains a persistent public health crisis, marked by poor treatment retention and limited pharmacotherapy options. Emerging treatments, such as psychedelic-assisted psychotherapy and neuromodulation, offer promising avenues for circuit-level interventions in behavioral addictions. This narrative review synthesizes the current landscape of psychedelic compounds and neuromodulation techniques with a focus on their mechanisms of action, applications in specific behavioral addictions, and translational potential. By targeting disrupted reward, executive control, and stress regulation networks, these interventions may facilitate meaningful recovery and long-term remission in otherwise treatment refractory cases. We highlight key findings, current research limitations, and future directions in integrating these novel therapies into the treatment of gambling disorder; internet gaming disorder/gaming disorder, predominantly online; internet use disorder; and compulsive sexual behavior disorder.
成瘾仍然是一个持续存在的公共卫生危机,其特点是治疗依从性差和药物治疗选择有限。新兴的治疗方法,如迷幻剂辅助心理治疗和神经调节,为行为成瘾的回路水平干预提供了有前景的途径。这篇叙述性综述综合了迷幻化合物和神经调节技术的当前情况,重点关注它们的作用机制、在特定行为成瘾中的应用以及转化潜力。通过针对受损的奖励、执行控制和压力调节网络,这些干预措施可能有助于在其他难治性病例中实现有意义的康复和长期缓解。我们强调了将这些新疗法整合到赌博障碍、互联网游戏障碍/主要是在线的游戏障碍、互联网使用障碍和强迫性行为障碍治疗中的关键发现、当前研究局限性以及未来方向。