Almén T
Department of Diagnostic Radiology, University of Lund, Malmö, Sweden.
Acta Radiol Suppl. 1977;355:419-30.
The non-ionic contrast medium metrizamide (Amipaque) was compared in animal experiments with diatrizoate, iothalamate and metrizoate. Vasodilatory effects, acute intravenous toxicity and effects on red blood cells, pulmonary arterial pressure, endothelium and heart were all less after metrizamide than after the ionic media. This motivated clinical trial of metrizamide for angiography, which demonstrated that metrizamide produced less pain than the ionic monomeric media in femoral as well as in other types of angiography.
在动物实验中，将非离子型造影剂甲泛葡胺（阿米培克）与泛影酸盐、碘他拉酸盐和甲泛影酸盐进行了比较。与离子型造影剂相比，甲泛葡胺引起的血管舒张效应、急性静脉毒性以及对红细胞、肺动脉压、内皮和心脏的影响均较小。这促使开展了甲泛葡胺用于血管造影的临床试验，结果表明在股动脉血管造影以及其他类型的血管造影中，甲泛葡胺引起的疼痛均比离子型单体造影剂少。
