Kunjir Harshal, Shetty Lakshmi, Sharma Dharmendra B, Aphale Parth, Gunturu Srikanth, Kunjir Girija, Chhatriwala Adnan F
Department of Oral and Maxillofacial Surgery, Dr. D.Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune 411018 India.
Department of Forensic Medicine and Toxicology, Dr. D. Y. Patil Homoeopathic Medical College and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune 411018 India.
Indian J Otolaryngol Head Neck Surg. 2025 Mar;77(3):1248-1255. doi: 10.1007/s12070-024-05312-4. Epub 2025 Jan 9.
Calendula officinalis has anti microbial and anti inflammatory property and its usage for wound healing is the need of the hour. The ultimate aim of our research study was to evaluate and compare bilateral earlobe rejuvenation with and without Calendula officinalis. The purpose of the study was to examine the impact of calendula on wound healing and its effect in the duration of wound healing. This randomised control trial was conducted on patients with bilateral earlobe cleft and were advised for the treatment of earlobe repair. The technique used for repair was Cross Stitching Approach modified with subcutaneus suturing. The randomization for the calendula application and sequence was generated randomly by computer generated random numbering. Calendula ointment was placed in a double blinded manner by blinding the principal investigator and the statistician. Calendula ointment was applied every 12 hourly on one ear lobe for a period of 7 days and petroleum jelly was placed on the contralateral earlobe. Scar assessment was done using the Stony Brook Scar Evaluation Scale (SBSE) on 15th day postoperatively. The wound healing after earlobe repair in 35 patients was compared after 24 h, 7 days, and 15 days using an unpaired t test in this randomized control trial. Statistical significance was defined as a P-value of less than 0.01. The repeated measures ANOVA test was used to compare mean scores at different time intervals in groups 1 and 2. The Bon Feronic test was used to compare the mean score in groups 1 and 2 at different time intervals. Statistical significance was defined as a p-value of less than 0.01. The comparison of mean score on day 1 the (p value = 0.525), day 7 was (p value = 0.324) and day 15 which was clinically significant (p value < 0.001). Calendula ointment was found to be beneficial in wound healing after cleft earlobe repair in this study. Calendula ointment has demonstrated potential benefits in treating wounds in scheduled surgery with no post-operative problems, according to the findings of this study. This study sets the landmark for the use of Calendula ointment in the treatment of cleft earlobe rejuvenation in Maxillofacial surgery.
金盏花具有抗菌和抗炎特性，当下其在伤口愈合方面的应用十分必要。我们研究的最终目的是评估和比较使用与不使用金盏花进行双侧耳垂年轻化的效果。该研究的目的是检验金盏花对伤口愈合的影响及其在伤口愈合持续时间方面的作用。这项随机对照试验针对双侧耳垂裂患者开展，并为他们提供耳垂修复治疗建议。修复所采用的技术是改良的交叉缝合方法并结合皮下缝合。金盏花应用及顺序的随机化是通过计算机生成随机编号随机产生的。金盏花软膏由主要研究者和统计学家在双盲状态下放置。金盏花软膏每12小时在一侧耳垂上涂抹一次，持续7天，对侧耳垂涂抹凡士林。术后第15天使用石溪瘢痕评估量表（SBSE）进行瘢痕评估。在这项随机对照试验中，采用不成对t检验比较了35例患者耳垂修复术后24小时、7天和15天的伤口愈合情况。统计学显著性定义为P值小于0.01。重复测量方差分析用于比较第1组和第2组在不同时间间隔的平均得分。Bon Feronic检验用于比较第1组和第2组在不同时间间隔的平均得分。统计学显著性定义为p值小于0.01。第1天平均得分的比较（p值 = 0.525），第7天（p值 = 0.324）以及第15天（具有临床显著性，p值 < 0.001）。在本研究中发现金盏花软膏对耳垂裂修复后的伤口愈合有益。根据本研究结果，金盏花软膏在择期手术伤口治疗中显示出潜在益处，且无术后问题。本研究为金盏花软膏在颌面外科耳垂裂年轻化治疗中的应用树立了标杆。
