Quan JingJing, Chen Li, Chen Weilin, Gong Ziwei, Li Si, Chen Hengbing, Huang Zhijun, Yi Bin
Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
Ren Fail. 2025 Dec;47(1):2478320. doi: 10.1080/0886022X.2025.2478320. Epub 2025 Mar 17.
Renal tubular damage, a pivotal pathological feature of chronic kidney disease (CKD), predicts disease progression. While extreme nighttime sleep duration is linked to glomerular injury by prior studies, its impact on tubular damage remains unclear. Given that 7-9 h of sleep per night is widely recommended for maintaining overall health, this study aimed to assess whether long nighttime sleep duration is associated with renal tubular damage using both observational and genetic evidence.
We analyzed 2,683 adults in rural China to assess the link between nighttime sleep duration and renal tubular damage (measured by retinol-binding protein and β2-microglobulin). Mendelian randomization (MR) analysis was performed to assess the causal relationship between prolonged nighttime sleep duration and elevated kidney injury molecule-1 (KIM-1) levels.
Multivariate logistic regression indicated that sleeping more than 9 h per night was associated with a 1.38-fold increased risk of renal tubular damage (95% CI: 1.11-1.71) compared to 7-9 h of sleep, with particularly pronounced effects observed in elderly individuals and women. MR analysis further supported a causal relationship between genetically predicted long nighttime sleep duration and elevated KIM-1 levels (: 0.994, 95% CI: 0.282-1.707), suggesting a genetic predisposition linking prolonged sleep duration with renal tubular damage.
Our findings provide observational and genetic evidence linking prolonged nighttime sleep to increased renal tubular damage risk. Given that 7-9 h of sleep per night is the widely accepted recommendation for maintaining overall health, our results emphasize the potential risks of excessive sleep duration exceeding 9 h.
肾小管损伤是慢性肾脏病（CKD）的关键病理特征，可预测疾病进展。虽然先前的研究表明极端夜间睡眠时间与肾小球损伤有关，但其对肾小管损伤的影响尚不清楚。鉴于每晚7 - 9小时的睡眠被广泛推荐用于维持整体健康，本研究旨在利用观察性和遗传学证据评估夜间睡眠时间过长是否与肾小管损伤有关。
我们分析了中国农村地区的2683名成年人，以评估夜间睡眠时间与肾小管损伤（通过视黄醇结合蛋白和β2微球蛋白测量）之间的联系。进行孟德尔随机化（MR）分析，以评估夜间睡眠时间延长与肾损伤分子1（KIM - 1）水平升高之间的因果关系。
多因素逻辑回归表明，与每晚睡7 - 9小时相比，每晚睡眠超过9小时与肾小管损伤风险增加1.38倍相关（95%置信区间：1.11 - 1.71），在老年人和女性中观察到的影响尤为明显。MR分析进一步支持了基因预测的夜间睡眠时间过长与KIM - 1水平升高之间的因果关系（：0.994，95%置信区间：0.282 - 1.707），表明存在将延长睡眠时间与肾小管损伤联系起来的遗传易感性。
我们的研究结果提供了观察性和遗传学证据，表明夜间睡眠时间延长与肾小管损伤风险增加有关。鉴于每晚7 - 9小时的睡眠是维持整体健康的广泛接受的建议，我们的结果强调了睡眠时间超过9小时的潜在风险。
