Egsgaard Sofie, Bliddal Mette, Jølving Line Riis, Liu Xiaoqin, Sonne Heidi, Munk-Olsen Trine
Research Unit of Child and Adolescent Psychiatry, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
BJOG. 2025 Jun;132(7):991-999. doi: 10.1111/1471-0528.18127. Epub 2025 Mar 17.
Undergoing medically assisted reproduction (MAR) has been linked to mixed mental health outcomes in women. We investigated the risk of postpartum depression (PPD) among mothers conceiving with MAR compared to mothers conceiving spontaneously.
Register-Based Study.
Denmark.
125 870 mothers with a PPD screening record who gave birth between 2015 and 2019.
We linked mothers' PPD screening records to national health registers and defined MAR conception linking childbirths to MAR treatments.
We defined PPD as an Edinburgh Postnatal Depression Scale score of ≥ 11. We performed logistic regression on the risk of PPD among mothers who conceived with MAR compared to spontaneous conception and further assessed variations according to duration, type, and indication for MAR.
The study population included 10 977 mothers with MAR conception and 114 893 with spontaneous conception, of which 767 (7%) and 8767 (8%) had PPD. We found a lower risk (adjusted risk ratio 0.87, 95% CI [0.80-0.93]) of PPD among mothers with MAR conception compared to spontaneous conception, with smaller variations according to type, duration and indication for MAR.
We observed a lower risk of PPD among mothers with MAR conception compared to mothers with spontaneous conception. While it is unlikely that MAR itself is protective of PPD, women who seek MAR may have a strong desire and psychological preparedness for parenthood, which could explain the observed findings. Among mothers conceiving with MAR, PPD risk may vary depending on the type of MAR treatment and underlying reasons for seeking MAR.
接受医学辅助生殖（MAR）与女性复杂的心理健康状况有关。我们调查了与自然受孕的母亲相比，通过MAR受孕的母亲产后抑郁（PPD）的风险。
基于登记的研究。
丹麦。
125870名在2015年至2019年间分娩且有PPD筛查记录的母亲。
我们将母亲的PPD筛查记录与国家健康登记册相链接，并将与MAR治疗相关的分娩定义为MAR受孕。
我们将PPD定义为爱丁堡产后抑郁量表得分≥11分。我们对通过MAR受孕的母亲与自然受孕的母亲患PPD的风险进行了逻辑回归分析，并根据MAR的持续时间、类型和指征进一步评估了差异。
研究人群包括10977名通过MAR受孕的母亲和114893名自然受孕的母亲，其中分别有767名（7%）和8767名（8%）患有PPD。我们发现，与自然受孕的母亲相比，通过MAR受孕的母亲患PPD的风险较低（调整风险比为0.87，95%CI[0.80-0.93]），且根据MAR的类型、持续时间和指征的差异较小。
我们观察到，与自然受孕的母亲相比，通过MAR受孕的母亲患PPD的风险较低。虽然MAR本身不太可能对PPD有保护作用，但寻求MAR的女性可能对为人父母有强烈的愿望和心理准备，这可以解释观察到的结果。在通过MAR受孕的母亲中，PPD风险可能因MAR治疗的类型和寻求MAR的潜在原因而异。
