Ding Zihan, Chen Yun, Huang Genbo, Liao Rongbo, Zhang Houting, Zhou Shifa, Liu XuKai
Department of Trauma and Acute Care Surgery, the 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Street, Nanchang, 330006, Jiangxi, China.
Department of Neurosurgery, the 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwai Street, Nanchang, 330006, Jiangxi, China.
J Health Popul Nutr. 2025 Mar 17;44(1):78. doi: 10.1186/s41043-025-00810-9.
Elderly individuals diagnosed with neuroblastoma and peripheral nervous system tumours often have a poor prognosis. However, there is currently a lack of comprehensive analysis on these conditions in older adults. This study aims to determine the global epidemiological trends of neuroblastoma and peripheral nervous system tumours (in individuals aged 60 and above).
We obtained cross-sectional data from the 2021 Global Burden of Disease, Injuries, and Risk Factors Study (GBD) ( https://vizhub.healthdata.org/gbd-results/ ). We assessed the burden of neuroblastoma and peripheral nervous system tumours in the elderly from 1990 to 2021 using indicators such as prevalence and incidence. These indicators were classified by global, national, and regional levels, further stratified by Socio-Demographic Index (SDI), age, and gender. The results are organized by SDI, age, and gender categories.
From 1990 to 2021, the global age-standardised prevalence and incidence rates of neuroblastoma and peripheral nervous system tumours among the elderly increased from 0.06 (95% UI 0.05, 0.08) and 0.12 (95% UI 0.09, 0.15) per 100,000 to 0.11 (95% UI 0.09, 0.13) and 0.22 (95% UI 0.17, 0.26) per 100,000, respectively. Age-standardised mortality and DALY rates also rose. Central Europe had the highest age-standardised prevalence and incidence rates in 2021, while Eastern Europe had the highest DALY rate. East Asia reported the highest number of total cases and experienced the fastest growth, with significant increases in prevalence, incidence, mortality, and DALY rates. Gender disparities were evident, with elderly men showing higher rates than women, and greater EAPC values indicating a higher increase in disease burden over time. The highest age-specific rates were found in the 90-94 age group, while the 70-74 age group had the highest DALY burden.
The continuous rise in the incidence of neuroblastoma and peripheral nervous system tumours among the elderly highlights a pressing the necessity for focused public health measures and improved treatment approaches. Addressing the regional, gender, and age-related disparities requires a comprehensive approach that integrates medical advancements, social support, and public health policies. Future research should explore potential risk factors and innovative therapies to mitigate this growing global health challenge.
被诊断患有神经母细胞瘤和周围神经系统肿瘤的老年人预后往往较差。然而，目前缺乏对老年人这些疾病状况的全面分析。本研究旨在确定神经母细胞瘤和周围神经系统肿瘤（60岁及以上人群）的全球流行病学趋势。
我们从2021年全球疾病、伤害及风险因素负担研究（GBD）（https://vizhub.healthdata.org/gbd-results/）中获取了横断面数据。我们使用患病率和发病率等指标评估了1990年至2021年老年人中神经母细胞瘤和周围神经系统肿瘤的负担。这些指标按全球、国家和地区层面进行分类，并进一步按社会人口指数（SDI）、年龄和性别进行分层。结果按SDI、年龄和性别类别进行整理。
1990年至2021年，全球老年人中神经母细胞瘤和周围神经系统肿瘤的年龄标准化患病率和发病率分别从每10万人0.06（95%UI 0.05，0.08）和0.12（95%UI 0.09，0.15）增至每10万人0.11（95%UI 0.09，0.13）和0.22（95%UI 0.17，0.26）。年龄标准化死亡率和伤残调整生命年率也有所上升。2021年，中欧的年龄标准化患病率和发病率最高，而东欧的伤残调整生命年率最高。东亚报告的病例总数最多，且增长最快，患病率、发病率、死亡率和伤残调整生命年率均显著上升。性别差异明显，老年男性的发病率高于女性，且年龄变化百分比（EAPC）值越大表明疾病负担随时间的增加越高。特定年龄发病率最高的是90 - 94岁年龄组，而70 - 74岁年龄组的伤残调整生命年负担最高。
老年人中神经母细胞瘤和周围神经系统肿瘤发病率的持续上升凸显了采取针对性公共卫生措施和改进治疗方法的迫切必要性。应对地区、性别和年龄相关的差异需要一种综合方法，将医学进步、社会支持和公共卫生政策结合起来。未来的研究应探索潜在风险因素和创新疗法，以应对这一日益严峻的全球健康挑战。
