Jáuregui Gretsen Velezmoro, Parpura Vladimir
International Translational Neuroscience Research Institute, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, P.R. China.
Ageing Longev. 2025 Feb;6(2):117-128. doi: 10.47855/jal9020-2025-2-3. Epub 2025 Feb 27.
Amyloid precursor protein (APP) is central to Alzheimer's disease (AD) by its role in Aβ build-up and in neuronal and astrocytic malfunction. The major risk factor for late-onset AD is aging, which increases APP processing in both neurons and astrocytes, and consequently increases Aβ production. This focused review covers the subjects of how aging and AD affect APP dynamics within the both cell types and how astrocytes dysfunction can enhance neuroinflammation and neuronal dysfunction and injury. We discuss the interplay between neurons and astrocytes in aging and AD brains, where bi-directional cellular interactions accelerate neurodegeneration.
淀粉样前体蛋白（APP）在阿尔茨海默病（AD）中起着核心作用，它参与β淀粉样蛋白（Aβ）的生成以及神经元和星形胶质细胞的功能异常。晚发型AD的主要风险因素是衰老，衰老会增加神经元和星形胶质细胞中APP的加工过程，从而增加Aβ的产生。这篇重点综述涵盖了衰老和AD如何影响这两种细胞类型内APP动态变化，以及星形胶质细胞功能障碍如何增强神经炎症、神经元功能障碍和损伤等主题。我们讨论了衰老和AD大脑中神经元与星形胶质细胞之间的相互作用，其中双向细胞间相互作用加速了神经退行性变。
