Chopra P
Jpn Heart J. 1985 Mar;26(2):227-34. doi: 10.1536/ihj.26.227.
Excised left atrial appendages were subjected to light and electron microscopy and histochemical analysis. Aschoff nodules (AN) showed strong acid phosphatase and nonspecific esterase activity. Ultrastructurally, the Aschoff cells had several features of fibroblasts and epithelioid cells. Rough endoplasmic reticulum (RER) was striking in most cells. Dilated cisterns of RER containing homogeneous material were also frequent. Mitochondria and ribosomes were present. AN thus seem to arise from mesenchymal tissues of the heart. It is likely that cross-reactivity between streptococcal antigen and myocardial connective tissue causes the cardiac histocyte/macrophage to transform to cells having features of epithelioid cells and/or fibroblasts.
对切除的左心耳进行光镜、电镜和组织化学分析。阿绍夫小体（AN）显示出强酸性磷酸酶和非特异性酯酶活性。超微结构上，阿绍夫细胞具有成纤维细胞和上皮样细胞的若干特征。大多数细胞中粗面内质网（RER）很显著。含有均匀物质的RER扩张池也很常见。存在线粒体和核糖体。因此，AN似乎起源于心脏的间充质组织。链球菌抗原与心肌结缔组织之间的交叉反应可能导致心脏组织细胞/巨噬细胞转化为具有上皮样细胞和/或成纤维细胞特征的细胞。
