Sasaki M, Matsuda T, Hohara T
Jpn J Clin Oncol. 1985 Apr;15 Suppl 1:235-41.
The occurrence of multiple primary malignant neoplasms in 607 patients with gastric cancer (404 males and 203 females) and 166 patients with peptic ulcer (136 males and 30 females) was examined by follow-up study. All patients were gastrectomized and had follow-up data from 2 to 13 years. The observed number of multiple primary cancer cases was compared with the expected number calculated from person-years of cases multiplied by the sex/age-specific incidence in Hokkaido. The frequency of a second primary cancer, including synchronous cancer, in gastric cancer patients was higher than that in peptic ulcer patients, and this tendency was also confirmed by the standardized incidence in the UICC standardized population. However, this difference disappeared after subtraction of synchronous cases. Therefore, the chance of a second cancer in gastric cancer patients seemed to be the same as that in the general population at least one year after the operation.
通过随访研究，对607例胃癌患者（404例男性和203例女性）和166例消化性溃疡患者（136例男性和30例女性）中多原发性恶性肿瘤的发生情况进行了检查。所有患者均接受了胃切除术，并拥有2至13年的随访数据。将观察到的多原发性癌病例数与根据病例人年数乘以北海道性别/年龄特异性发病率计算出的预期数进行比较。胃癌患者中包括同时性癌在内的第二原发性癌的发生率高于消化性溃疡患者，这种趋势在国际抗癌联盟（UICC）标准化人群的标准化发病率中也得到了证实。然而，在减去同时性病例后，这种差异消失了。因此，胃癌患者发生第二癌症的几率在术后至少一年似乎与普通人群相同。
