Sakai K, Sueyama H, Saito M, Kitamura T
Gan No Rinsho. 1984 Sep;30(12 Suppl):1524-9.
This study of 502 patients with malignant lymphoma revealed the following: In all, 18 cases (3.6%) of histologically confirmed multiple primary cancers were found. Eleven cases of second malignancies were observed after diagnosis of malignant lymphoma, whereas 7 cases of malignant lymphoma occurred after other malignancies. The expected number of second malignancies in 502 patients with malignant lymphoma was calculated as 4.94 by the person-years approach. The observed number (11) was significantly higher than the expected (p less than 0.01). There was, however, no case of second malignancy considered to be related to the previous radiotherapy.
对502例恶性淋巴瘤患者的这项研究揭示了以下情况：总共发现18例（3.6%）经组织学确诊的多原发性癌。在恶性淋巴瘤诊断后观察到11例第二原发性恶性肿瘤，而7例恶性淋巴瘤在其他恶性肿瘤之后发生。采用人年法计算502例恶性淋巴瘤患者中第二原发性恶性肿瘤的预期数量为4.94。观察到的数量（11）显著高于预期数量（p<0.01）。然而，没有第二原发性恶性肿瘤病例被认为与先前的放射治疗有关。
