[1962年至1981年期间国立癌症中心的多原发性恶性肿瘤]
[Multiple primary malignant neoplasms in the national cancer center during 1962-1981].
作者信息
Watanabe S
出版信息
Gan No Rinsho. 1984 Sep;30(12 Suppl):1489-98.
Four hundred and eight cases with multiple primary malignant neoplasms from 5,456 autopsy cases were reviewed, and their age, sex, sites and relationship between the two cancers were analysed. Expected number of the second cancer was calculated based upon the person-years of 8,444 cases with primary gastro-intestinal cancers. Significant higher incidence was observed in the oropharyngeal cancer, esophageal cancer in male, and colon cancer in female. Organ relationship was present along the gastrointestinal tract, as observed in autopsy cases. Biological meaning of multiple primary malignant neoplasms was discussed.
回顾了5456例尸检病例中的408例多原发性恶性肿瘤病例，并分析了其年龄、性别、肿瘤部位以及两种癌症之间的关系。根据8444例原发性胃肠道癌症病例的人年数计算了第二种癌症的预期病例数。结果发现，口咽癌、男性食管癌和女性结肠癌的发病率显著更高。正如尸检病例中所观察到的，多原发性恶性肿瘤在胃肠道存在器官关联性。本文还讨论了多原发性恶性肿瘤的生物学意义。
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