Zhang Yuan, Feng Jiangtao, Yang Hongxi, Li Shu
Department of Pathology, Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of orthopedic, Tianjin NanKai Hospital, Tianjin, China.
Int J Surg. 2025 May 1;111(5):3672-3676. doi: 10.1097/JS9.0000000000002348.
Chronic musculoskeletal pain (CMP) is associated with the risk of dementia, yet little is known about whether this association is modified by APOE genotype and whether analgesics may mitigate the risk effect of CMP on dementia. This prospective cohort study, included 415 072 participants from UK Biobank, found that CMP was associated with a higher risk of dementia, and this association may be modified by the APOE genotype. Analgesics may not mitigate the risk effect of CMP on dementia.
慢性肌肉骨骼疼痛（CMP）与痴呆风险相关，但对于这种关联是否会因载脂蛋白E（APOE）基因型而改变，以及镇痛药是否可以减轻CMP对痴呆的风险影响，人们知之甚少。这项前瞻性队列研究纳入了英国生物银行的415072名参与者，发现CMP与较高的痴呆风险相关，并且这种关联可能会因APOE基因型而改变。镇痛药可能无法减轻CMP对痴呆的风险影响。
